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Gene Review

SRPRB  -  signal recognition particle receptor, B...

Homo sapiens

Synonyms: APMCF1, PSEC0230, Protein APMCF1, SR-beta, Signal recognition particle receptor subunit beta
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High impact information on SRPRB

  • SRbeta coordinates signal sequence release from SRP with ribosome binding to the translocon [1].
  • Using a soluble form of SR and an XTP-binding mutant of SRbeta, we show that SRbeta is essential for protein translocation across the ER membrane [1].
  • The SRP receptor consists of two subunits, SR alpha and SR beta, both tightly associated with the ER membrane [2].
  • An SRbeta mutant containing an amino acid substitution that allows the GTPase domain to bind XTP dimerized with SRalpha most efficiently in the presence of XTP or XDP, but not ATP [3].
  • Deletion of the amino-terminal transmembrane domain of SRbeta did not affect receptor dimerization, but revealed a cryptic translocation signal that overlaps the GTPase domain [3].

Anatomical context of SRPRB

  • We found that SRbeta binds GTP with high affinity and interacts with ribosomes in the GTP-bound state [4].
  • The only well established function for the transmembrane SRbeta subunit is anchoring SRalpha on the endoplasmic reticulum membrane [3].

Associations of SRPRB with chemical compounds


Other interactions of SRPRB

  • The transmembrane protein SR beta also contains a GTPase domain, but it is not closely related to those of SRP54 and SR alpha [5].

Analytical, diagnostic and therapeutic context of SRPRB


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