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Gene Review

EPS15L1  -  epidermal growth factor receptor pathway...

Homo sapiens

Synonyms: EPS15R, Epidermal growth factor receptor substrate 15-like 1, Eps15-related protein, Eps15R, eps15R
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High impact information on EPS15L1

  • EH is a recently identified protein-protein interaction domain found in the signal transducers Eps15 and Eps15R and several other proteins of yeast nematode [1].
  • In this study, we demonstrate that Eps15 and Eps15R, two EH-containing proteins, synergize with Hrb and Hrbl to enhance the function of Rev in the export pathway [2].
  • Furthermore, we show that BRII interacts with Eps15R, a constitutive component of CCPs, and with caveolin-1, the marker protein of caveolae [3].
  • Indirect evidence suggests that eps15 and eps15R are involved in endocytosis [4].
  • In contrast, no NES could be found in Eps15R, a result in keeping with its constitutive nuclear localization that appears to be regulated by alternative splicing [5].

Other interactions of EPS15L1

  • Eps15 and its related protein Eps15R are key components of the clathrin-mediated endocytic pathway [6].


  1. Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module. Salcini, A.E., Confalonieri, S., Doria, M., Santolini, E., Tassi, E., Minenkova, O., Cesareni, G., Pelicci, P.G., Di Fiore, P.P. Genes Dev. (1997) [Pubmed]
  2. The eps15 homology (EH) domain-based interaction between eps15 and hrb connects the molecular machinery of endocytosis to that of nucleocytosolic transport. Doria, M., Salcini, A.E., Colombo, E., Parslow, T.G., Pelicci, P.G., Di Fiore, P.P. J. Cell Biol. (1999) [Pubmed]
  3. Different Routes of Bone Morphogenic Protein (BMP) Receptor Endocytosis Influence BMP Signaling. Hartung, A., Bitton-Worms, K., Rechtman, M.M., Wenzel, V., Boergermann, J.H., Hassel, S., Henis, Y.I., Knaus, P. Mol. Cell. Biol. (2006) [Pubmed]
  4. eps15 and eps15R are essential components of the endocytic pathway. Carbone, R., Fré, S., Iannolo, G., Belleudi, F., Mancini, P., Pelicci, P.G., Torrisi, M.R., Di Fiore, P.P. Cancer Res. (1997) [Pubmed]
  5. Differential nucleocytoplasmic trafficking between the related endocytic proteins Eps15 and Eps15R. Poupon, V., Polo, S., Vecchi, M., Martin, G., Dautry-Varsat, A., Cerf-Bensussan, N., Di Fiore, P.P., Benmerah, A. J. Biol. Chem. (2002) [Pubmed]
  6. Ubiquilin recruits Eps15 into ubiquitin-rich cytoplasmic aggregates via a UIM-UBL interaction. Regan-Klapisz, E., Sorokina, I., Voortman, J., de Keizer, P., Roovers, R.C., Verheesen, P., Urbé, S., Fallon, L., Fon, E.A., Verkleij, A., Benmerah, A., van Bergen en Henegouwen, P.M. J. Cell. Sci. (2005) [Pubmed]
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