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Eps15l1  -  epidermal growth factor receptor pathway...

Mus musculus

Synonyms: 9830147J04Rik, AI593686, Epidermal growth factor receptor pathway substrate 15-related sequence, Epidermal growth factor receptor substrate 15-like 1, Eps15-related protein, ...
 
 
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High impact information on Eps15l1

  • Using an EH domain-specific probe derived from the eps15 cDNA, we cloned and characterized a cDNA encoding an EH-containing protein with overall similarity to Eps15; we designated this protein Eps15r (for Eps15-related) [1].
  • Eps15R protein(s) are tyrosine-phosphorylated following epidermal growth factor receptor activation in NIH-3T3 cells overexpressing the receptor, even at low levels of receptor occupancy, thus behaving as physiological substrates [2].
  • Eps15R is a tyrosine kinase substrate with characteristics of a docking protein possibly involved in coated pits-mediated internalization [2].
  • Eps15 and Eps15R bound specifically to the amino-terminal SH3 domain of Crk and coprecipitated equivalently with both c-Crk and v-Crk from cell lysates [3].
  • Differential patterns of expression of Eps15 and Eps15R during mouse embryogenesis [4].
 

Biological context of Eps15l1

 

Anatomical context of Eps15l1

  • The most striking difference was at the level of subcellular localization, with Eps15 present in the cytosol and on the plasma membrane, while Eps15R exhibited mainly a nuclear localization [4].
 

Other interactions of Eps15l1

  • Nuclear staining of Eps15R was present in kidney, intestine, lung and liver, as well as in heart and pancreas [4].
  • In the 12.5 days post coitum neuroepithelium, Eps15 was expressed in the ventricular zone, which contains proliferating neuroblasts, whereas Eps15R was found only in postmitotic neurons [4].

References

  1. A protein-binding domain, EH, identified in the receptor tyrosine kinase substrate Eps15 and conserved in evolution. Wong, W.T., Schumacher, C., Salcini, A.E., Romano, A., Castagnino, P., Pelicci, P.G., Di Fiore, P. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  2. Eps15R is a tyrosine kinase substrate with characteristics of a docking protein possibly involved in coated pits-mediated internalization. Coda, L., Salcini, A.E., Confalonieri, S., Pelicci, G., Sorkina, T., Sorkin, A., Pelicci, P.G., Di Fiore, P.P. J. Biol. Chem. (1998) [Pubmed]
  3. The SH3 domain of Crk binds specifically to a conserved proline-rich motif in Eps15 and Eps15R. Schumacher, C., Knudsen, B.S., Ohuchi, T., Di Fiore, P.P., Glassman, R.H., Hanafusa, H. J. Biol. Chem. (1995) [Pubmed]
  4. Differential patterns of expression of Eps15 and Eps15R during mouse embryogenesis. Offenhäuser, N., Santolini, E., Simeone, A., Di Fiore, P.P. Mech. Dev. (2000) [Pubmed]
 
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