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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

RGL2  -  ral guanine nucleotide dissociation...

Homo sapiens

Synonyms: HKE1.5, KE1.5, RAB2L, Ral guanine nucleotide dissociation stimulator-like 2, RalGDS-like 2, ...
 
 
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High impact information on RGL2

  • Finally, coexpression of RGL2 C-158 impaired oncogenic Ras activation of transcription from a Ras-responsive promoter element and focus-forming activity in NIH 3T3 cells [1].
  • Transcription of the ABI3 and RGL2 genes is up-regulated by glucose [2].
  • The inhibitory effect on seed germination seems to be accomplished via the activation of the ABA signalling pathway, through ABI3, and inactivation of the GA signalling pathway through RGL2 and SPY [2].
  • Five singly spin labeled side chains at surface sites in the C-terminal domain of RGL2 protein have been analyzed to investigate the general relationship between nitroxide side chain mobility and protein structure [3].
  • We have isolated a novel human cDNA, designated RAB2L, that encodes a protein homologous to Ral guanine nucleotide dissociation stimulator (RalGDS) [4].
 

Other interactions of RGL2

  • Isolation and mapping of RAB2L, a human cDNA that encodes a protein homologous to RalGDS [4].

References

  1. Identification of a novel RalGDS-related protein as a candidate effector for Ras and Rap1. Peterson, S.N., Trabalzini, L., Brtva, T.R., Fischer, T., Altschuler, D.L., Martelli, P., Lapetina, E.G., Der, C.J., White, G.C. J. Biol. Chem. (1996) [Pubmed]
  2. Phytohormone signalling pathways interact with sugars during seed germination and seedling development. Yuan, K., Wysocka-Diller, J. J. Exp. Bot. (2006) [Pubmed]
  3. Molecular motion of spin labeled side chains in the C-terminal domain of RGL2 protein: a SDSL-EPR and MD study. Pistolesi, S., Ferro, E., Santucci, A., Basosi, R., Trabalzini, L., Pogni, R. Biophys. Chem. (2006) [Pubmed]
  4. Isolation and mapping of RAB2L, a human cDNA that encodes a protein homologous to RalGDS. Isomura, M., Okui, K., Fujiwara, T., Shin, S., Nakamura, Y. Cytogenet. Cell Genet. (1996) [Pubmed]
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