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Gene Review

Erbb2ip  -  Erbb2 interacting protein

Mus musculus

Synonyms: 1700028E05Rik, Densin-180-like protein, Erbb2-interacting protein, Erbin, Kiaa1225, ...
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High impact information on Erbb2ip

  • Collectively, these data indicate that erbin regulates MAP kinase activation in Schwann cells and suggest that erbin links merlin to both adherens junction protein complexes and the MAP kinase signaling pathway [1].
  • Here, we find that a novel PDZ protein, called erbin, binds directly to the merlin-binding partner, EBP0, and regulates adherens junction dissociation through a MAP kinase-dependent mechanism [1].
  • These phenotypes can be rescued if cells with reduced levels of erbin are treated with a pharmacological inhibitor of ERK kinase [1].

Anatomical context of Erbb2ip


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