Gene Review:
RAP2B - RAP2B, member of RAS oncogene family
Homo sapiens
Synonyms:
Ras-related protein Rap-2b
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Disease relevance of RAP2B
- Oligonucleotides were synthesized to complete the amino acid sequence of the RAP2B protein and the entire sequence was expressed in Escherichia coli [1].
High impact information on RAP2B
- RAP2B is 90% identical to RAP2 at the amino acid level with the most variability at the carboxyl terminus of the protein [1].
- Moreover, incubation of similar extracts with the catalytic subunit of cAMP-dependent protein kinase did not cause phosphorylation of RAP2B, as had been observed for the closely homologous proteins, RAP1A and RAP1B [1].
- A repeated screening of the platelet cDNA library with an internal Ava I fragment of the RAP2B cDNA allowed the isolation of a full-length cDNA for the RAP2B sequence [1].
References
- RAP2B: a RAS-related GTP-binding protein from platelets. Ohmstede, C.A., Farrell, F.X., Reep, B.R., Clemetson, K.J., Lapetina, E.G. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
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