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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

pax5  -  paired box 5

Danio rerio

Synonyms: Pax[Zf-b], SO:0000704, noi, pax2.1, pax2a, ...
 
 
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High impact information on pax5

  • Anterior markers pax5 and nkx5.1 are expressed in expanded domains that include the entire otic epithelium juxtaposed to the hindbrain, and the posterior marker zp23 is not expressed [1].
  • Otic expression of pax5 requires pax2a and fgf3, mutations in which cause vestibular defects, albeit by distinct mechanisms [2].

References

  1. An expanded domain of fgf3 expression in the hindbrain of zebrafish valentino mutants results in mis-patterning of the otic vesicle. Kwak, S.J., Phillips, B.T., Heck, R., Riley, B.B. Development (2002) [Pubmed]
  2. Zebrafish pax5 regulates development of the utricular macula and vestibular function. Kwak, S.J., Vemaraju, S., Moorman, S.J., Zeddies, D., Popper, A.N., Riley, B.B. Dev. Dyn. (2006) [Pubmed]
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