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Gene Review

fgf3  -  fibroblast growth factor 3

Danio rerio

Synonyms: FGF-3, Fibroblast growth factor 3, HBGF-3, Heparin-binding growth factor 3, SO:0000704, ...
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High impact information on fgf3

  • We propose a model in which mesoderm-derived Fgf3 and Fgf8 signals establish both the EB placodes and the development of the pharyngeal endoderm, the subsequent interaction of which promotes neurogenesis [1].
  • During normal development, ascl1a is expressed in the adenohypophysis and the adjacent diencephalon, the source of Fgf3 signals [2].
  • Together, this suggests that Ascl1a might act downstream of diencephalic Fgf3 signaling to mediate some of the effects of Fgf3 on the developing adenohypophysis [2].
  • Surprisingly, ectodermal foxi1 expression, a marker for the epibranchial placode precursors, is present in both endoderm-deficient embryos and fgf3 morphants, indicating that neither endoderm nor Fgf3 is required for initial placode induction [3].
  • Furthermore, ectopic fgf3 expression is sufficient for inducing phox2a-positive neurons in wild-type and endoderm-deficient embryos [3].

Biological context of fgf3

  • 3. In foo/foo embryos, we observed a failure to maintain fgf3 expression in the pouches, followed by apoptosis of neural crest cells in adjacent arches [4].
  • Injections of high doses of Spry4 cause ventralization of the embryo, an opposite phenotype to the dorsalisation induced by overexpression of Fgf8 or Fgf3 [5].

Anatomical context of fgf3

  • Zebrafish fgf3 is expressed in the correct place (dorsolateral margin) and at the correct time (late blastula to early gastrula stages), the same point that the most precocious posterior neural marker, hoxb1b, is first activated [6].
  • The delay in otic induction correlates closely with delayed expression of fgf3 and fgf8 in the hindbrain [7].
  • In addition, fgf3 is expressed during the latter half of gastrulation in the prechordal plate and paraxial cephalic mesendoderm, tissues that either pass beneath or persist near the prospective otic ectoderm [8].
  • Using a genetic interference approach, we further identify Fgf3 as a critical component of endodermal function that allows the development of posterior arch cartilages [9].
  • Within the diencephalon, Fgf3 and Fgf8 act synergistically to pattern the ventral thalamus, and are implicated in the regulation of optic stalk formation, whereas loss of Fgf3 alone results in defects in ZLI development [10].

Associations of fgf3 with chemical compounds

  • Conversely, treatment of wild-type embryos with retinoic acid greatly expands the periotic domains of expression of fgf3, fgf8, and pax8 and leads to formation of supernumerary and ectopic otic vesicles [8].

Other interactions of fgf3

  • Conditions that alter the pattern of expression of fgf3 and/or fgf8 cause corresponding changes in otic induction [8].
  • However, this effect was mediated by Chordino (zebrafish Chordin), because Fgf3 induces chordino expression in the epiblast and Fgf3-induced neural expansion was substantially suppressed in dino mutants with mutated chordino genes [6].
  • Unique and combinatorial functions of Fgf3 and Fgf8 during zebrafish forebrain development [10].
  • A number of studies indicate that fibroblast growth factor (Fgf), especially Fgf3, is necessary and sufficient for otic induction [7].

Analytical, diagnostic and therapeutic context of fgf3


  1. Specification of epibranchial placodes in zebrafish. Nechiporuk, A., Linbo, T., Poss, K.D., Raible, D.W. Development (2007) [Pubmed]
  2. The proneural gene ascl1a is required for endocrine differentiation and cell survival in the zebrafish adenohypophysis. Pogoda, H.M., von der Hardt, S., Herzog, W., Kramer, C., Schwarz, H., Hammerschmidt, M. Development (2006) [Pubmed]
  3. Endoderm-derived Fgf3 is necessary and sufficient for inducing neurogenesis in the epibranchial placodes in zebrafish. Nechiporuk, A., Linbo, T., Raible, D.W. Development (2005) [Pubmed]
  4. Zebrafish foxi one modulates cellular responses to Fgf signaling required for the integrity of ear and jaw patterning. Nissen, R.M., Yan, J., Amsterdam, A., Hopkins, N., Burgess, S.M. Development (2003) [Pubmed]
  5. sprouty4 acts in vivo as a feedback-induced antagonist of FGF signaling in zebrafish. Fürthauer, M., Reifers, F., Brand, M., Thisse, B., Thisse, C. Development (2001) [Pubmed]
  6. Inhibition of BMP activity by the FGF signal promotes posterior neural development in zebrafish. Koshida, S., Shinya, M., Nikaido, M., Ueno, N., Schulte-Merker, S., Kuroiwa, A., Takeda, H. Dev. Biol. (2002) [Pubmed]
  7. A direct role for Fgf but not Wnt in otic placode induction. Phillips, B.T., Storch, E.M., Lekven, A.C., Riley, B.B. Development (2004) [Pubmed]
  8. Zebrafish fgf3 and fgf8 encode redundant functions required for otic placode induction. Phillips, B.T., Bolding, K., Riley, B.B. Dev. Biol. (2001) [Pubmed]
  9. Requirement for endoderm and FGF3 in ventral head skeleton formation. David, N.B., Saint-Etienne, L., Tsang, M., Schilling, T.F., Rosa, F.M. Development (2002) [Pubmed]
  10. Unique and combinatorial functions of Fgf3 and Fgf8 during zebrafish forebrain development. Walshe, J., Mason, I. Development (2003) [Pubmed]
  11. FGF3 and FGF8 mediate a rhombomere 4 signaling activity in the zebrafish hindbrain. Maves, L., Jackman, W., Kimmel, C.B. Development (2002) [Pubmed]
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