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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

pax8  -  paired box 8

Danio rerio

Synonyms: SO:0000704
 
 
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High impact information on pax8

  • Our results further provide evidence that pax8 expression and pax2a expression are regulated by two independent factors, Foxi1 and Dlx3b, respectively [1].
  • We conclude that foo expression is essential for pax8 expression probably downstream of Fgf signaling in a conserved pathway jointly required for integrity of patterning in the otic placode and pharyngeal pouches [2].
  • Moreover, preplacode cells fail to express pax8 and pax2.1, indicating disruption of early stages of otic induction in fgf3-depleted ace/ace mutants [3].

References

  1. Pax8 and Pax2a function synergistically in otic specification, downstream of the Foxi1 and Dlx3b transcription factors. Hans, S., Liu, D., Westerfield, M. Development (2004) [Pubmed]
  2. Zebrafish foxi one modulates cellular responses to Fgf signaling required for the integrity of ear and jaw patterning. Nissen, R.M., Yan, J., Amsterdam, A., Hopkins, N., Burgess, S.M. Development (2003) [Pubmed]
  3. Zebrafish fgf3 and fgf8 encode redundant functions required for otic placode induction. Phillips, B.T., Bolding, K., Riley, B.B. Dev. Biol. (2001) [Pubmed]
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