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Gene Review

foxi1  -  forkhead box i1

Danio rerio

Synonyms: SO:0000704, cb724, foo
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High impact information on foxi1

  • Finally, both Fgf3 and Fgf8 are sufficient to induce foxi1-positive placodal precursors in wild-type as well as Fgf3-plus Fgf8-depleted embryos [1].
  • In contrast, the phenotype caused by disrupting foxi1, which is required for pax8 expression, was not enhanced by simultaneously disrupting pax8 [2].
  • We conclude that foo expression is essential for pax8 expression probably downstream of Fgf signaling in a conserved pathway jointly required for integrity of patterning in the otic placode and pharyngeal pouches [3].
  • In the absence of foxi1 activity, progenitor cells fail to express the basic helix-loop-helix gene neurogenin that is essential for the formation of neuronal precursors, and the paired homeodomain containing gene phox2a that is essential for neuronal differentiation and maintenance [4].
  • In addition, foxi1 is expressed in the developing branchial arches, and jaw formation is disrupted in hearsay mutant embryos [5].

Biological context of foxi1


Anatomical context of foxi1

  • Surprisingly, ectodermal foxi1 expression, a marker for the epibranchial placode precursors, is present in both endoderm-deficient embryos and fgf3 morphants, indicating that neither endoderm nor Fgf3 is required for initial placode induction [6].
  • None of these newly identified FoxI genes are expressed in otic precursor cells and, therefore, are unlikely to share functional overlap with foxi1 in the development of the inner ear [7].

Other interactions of foxi1

  • Depletion of both foxi1 and dlx3b results in a complete ablation of otic placode formation [8].


  1. Specification of epibranchial placodes in zebrafish. Nechiporuk, A., Linbo, T., Poss, K.D., Raible, D.W. Development (2007) [Pubmed]
  2. Zebrafish pax8 is required for otic placode induction and plays a redundant role with Pax2 genes in the maintenance of the otic placode. Mackereth, M.D., Kwak, S.J., Fritz, A., Riley, B.B. Development (2005) [Pubmed]
  3. Zebrafish foxi one modulates cellular responses to Fgf signaling required for the integrity of ear and jaw patterning. Nissen, R.M., Yan, J., Amsterdam, A., Hopkins, N., Burgess, S.M. Development (2003) [Pubmed]
  4. The zebrafish forkhead transcription factor Foxi1 specifies epibranchial placode-derived sensory neurons. Lee, S.A., Shen, E.L., Fiser, A., Sali, A., Guo, S. Development (2003) [Pubmed]
  5. Zebrafish foxi1 mediates otic placode formation and jaw development. Solomon, K.S., Kudoh, T., Dawid, I.B., Fritz, A. Development (2003) [Pubmed]
  6. Endoderm-derived Fgf3 is necessary and sufficient for inducing neurogenesis in the epibranchial placodes in zebrafish. Nechiporuk, A., Linbo, T., Raible, D.W. Development (2005) [Pubmed]
  7. Expression and phylogenetic analyses of three zebrafish FoxI class genes. Solomon, K.S., Logsdon, J.M., Fritz, A. Dev. Dyn. (2003) [Pubmed]
  8. Genetic interactions underlying otic placode induction and formation. Solomon, K.S., Kwak, S.J., Fritz, A. Dev. Dyn. (2004) [Pubmed]
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