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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

RNU7-68P  -  RNA, U7 small nuclear 68 pseudogene

Homo sapiens

Synonyms: HSU7.732A, RNU7P1, U7, U7.68
 
 
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Disease relevance of RNU7P1

 

High impact information on RNU7P1

  • Efficient 3'-end processing of cell cycle-regulated mammalian histone premessenger RNAs (pre-mRNAs) requires an upstream stem-loop and a histone downstream element (HDE) that base pairs with the U7 small ribonucleoprotein [2].
  • We used Xenopus oocytes to ask whether compensatory length insertions in the human U7 RNA could restore the fidelity and efficiency of processing of mouse histone insertion pre-mRNAs [2].
  • Exon skipping with U7 gene transfer [3].
 

Biological context of RNU7P1

  • Yet, the noncomplementary insertion mutant U7 was shown to be active on insertion substrates further mutated to allow base pairing [2].

References

  1. Detection of a gene cluster that is dispensable for human herpesvirus 6 replication and latency. Kondo, K., Nozaki, H., Shimada, K., Yamanishi, K. J. Virol. (2003) [Pubmed]
  2. Length suppression in histone messenger RNA 3'-end maturation: processing defects of insertion mutant premessenger RNAs can be compensated by insertions into the U7 small nuclear RNA. Scharl, E.C., Steitz, J.A. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  3. Exon skipping with U7 gene transfer. Scheuerbrandt, G. Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology / edited by the Gaetano Conte Academy for the study of striated muscle diseases. (2006) [Pubmed]
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