The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

Table of contents

About

Terms

 

Gene Review: 

DEFA1A3  -  defensin, alpha 1 and alpha 3, variable...

Homo sapiens

Synonyms: DEFA1, DEFA3, DEFT1P
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on DEFA1A3

  • The total number of gene copies per diploid genome varied between four and 11 in a sample of 111 control individuals from the UK, with approximately 10% (11/111) of people lacking DEFA3 completely [1].
  • Inter-population variability of DEFA3 gene absence: correlation with haplotype structure and population variability [2].
  • Association analysis of DEFA3 absence with 136 SNPs from a 100-kb region identified a conserved haplotype in the Caucasian population, extending for the whole region [2].
  • The alpha-defensin cluster on human chromosome 8p23.1 is one of the better-characterized CNVs, in which high copy number variability affecting the DEFA1 and DEFA3 genes has been reported [2].

References

  1. Copy number polymorphism and expression level variation of the human alpha-defensin genes DEFA1 and DEFA3. Aldred, P.M., Hollox, E.J., Armour, J.A. Hum. Mol. Genet. (2005) [Pubmed]
  2. Inter-population variability of DEFA3 gene absence: correlation with haplotype structure and population variability. Ballana, E., González, J.R., Bosch, N., Estivill, X. BMC Genomics (2007) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities