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Gene Review

RPL30  -  ribosomal protein L30

Homo sapiens

Synonyms: 60S ribosomal protein L30, L30
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Disease relevance of RPL30

  • We demonstrate that gain of 8q and expression levels of three 8q-mapped candidate genes (EEF1D, RPL30, RPS20) are associated with adverse outcome in medulloblastoma [1].
  • Unlike that of other acutely transforming retroviruses, transduction of the v-ryk gene into RPL30 did not result in deletion of viral sequences [2].
  • Partial amino acid sequencing of AT-L30 preparations from several strains proved that we were indeed dealing with the specified protein homologous to ribosomal protein L30 of Escherichia coli [3].

High impact information on RPL30

  • The Saccharomyces cerevisiae ribosomal protein L30 autoregulates its own expression by binding to a purine-rich internal loop in its pre-mRNA and mRNA [4].
  • By reconstitution of a virus from its cDNA, the v-ryk oncogene has been shown to be fully responsible for the transforming activity of the RPL30 virus [2].
  • Medulloblastoma outcome is adversely associated with overexpression of EEF1D, RPL30, and RPS20 on the long arm of chromosome 8 [1].


  1. Medulloblastoma outcome is adversely associated with overexpression of EEF1D, RPL30, and RPS20 on the long arm of chromosome 8. De Bortoli, M., Castellino, R.C., Lu, X.Y., Deyo, J., Sturla, L.M., Adesina, A.M., Perlaky, L., Pomeroy, S.L., Lau, C.C., Man, T.K., Rao, P.H., Kim, J.Y. BMC Cancer (2006) [Pubmed]
  2. A novel oncogene, v-ryk, encoding a truncated receptor tyrosine kinase is transduced into the RPL30 virus without loss of viral sequences. Jia, R., Mayer, B.J., Hanafusa, T., Hanafusa, H. J. Virol. (1992) [Pubmed]
  3. Polyacrylamide gel electrophoresis analysis of ribosomal protein AT-L30 as a novel approach to actinomycete taxonomy: application to the genera Actinomadura and Microtetraspora. Ochi, K., Miyadoh, S., Tamura, T. Int. J. Syst. Bacteriol. (1991) [Pubmed]
  4. Inherent protein structural flexibility at the RNA-binding interface of L30e. Chao, J.A., Prasad, G.S., White, S.A., Stout, C.D., Williamson, J.R. J. Mol. Biol. (2003) [Pubmed]
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