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Gene Review:

RPS8 - ribosomal protein S8

Homo sapiens

Synonyms: 40S ribosomal protein S8, OK/SW-cl.83, S8

Davies, B. et al., Paterakis, K. et al., Nakamura, I. et al., Toshimitsu, H. et al.

Toshimitsu, Iizuka, Yamamoto, Kawauchi, Oga, Furuya, Oka, Sasaki,

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Disease relevance of RPS8

Escherichia coli ribosomal protein S8 has been subjected to mild proteolytic digestion in order to search for structural domains within the protein [1] [1].

High impact information on RPS8

Nucleotide sequence of a rice cDNA encoding a homolog of the eukaryotic ribosomal protein S8 [2].
The human RPS8 gene is 3161 bp in length and comprises six exons [3].
The DNA sequence 5' to the RPS8 gene and within the first exon and intron shows several features of a CpG island [3].
The microarray data for two of these genes, SPARC and RPS8, were validated by RT-PCR [4].

Analytical, diagnostic and therapeutic context of RPS8

A combination of Southern blotting, PCR, and fluorescence in situ hybridization analyses has enabled the chromosomal location of the human RPS8 gene to be determined as 1p32-p34.1 [3].

References

Structural domains of ribosomal protein S8 and their relationship to ribosomal RNA binding. Paterakis, K., Littlechild, J. FEBS Lett. (1982) [Pubmed]
Nucleotide sequence of a rice cDNA encoding a homolog of the eukaryotic ribosomal protein S8. Nakamura, I., Kameya, N., Aoki, T., Tada, T., Norita, E., Kanzaki, H., Uchimiya, H. Plant Physiol. (1995) [Pubmed]
The structure of the human intron-containing S8 ribosomal protein gene and determination of its chromosomal location at 1p32-p34.1. Davies, B., Fried, M. Genomics (1993) [Pubmed]
Molecular features linked to the growth-inhibitory effects of gemcitabine on human pancreatic cancer cells. Toshimitsu, H., Iizuka, N., Yamamoto, K., Kawauchi, S., Oga, A., Furuya, T., Oka, M., Sasaki, K. Oncol. Rep. (2006) [Pubmed]

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AgaP_AGAP002437	Anopheles gambiae str. PEST
AT5G59240	Arabidopsis thaliana
AGOS_AGR375W	Ashbya gossypii ATCC 10895
RPS8	Bos taurus
rps-8	Caenorhabditis elegans
RPS8	Canis lupus familiaris
rps8b	Danio rerio
RpS8	Drosophila melanogaster
RPS8	Gallus gallus
KLLA0E20461g	Kluyveromyces lactis NRRL Y-1140
LOC696015	Macaca mulatta
MGG_03251	Magnaporthe oryzae 70-15
Rps8	Mus musculus
NCU08500	Neurospora crassa OR74A
Rps8	Rattus norvegicus
RPS8A	Saccharomyces cerevisiae S288c
RPS8B	Saccharomyces cerevisiae S288c
rps802	Schizosaccharomyces pombe 972h-
rps801	Schizosaccharomyces pombe 972h-
rps8	Xenopus (Silurana) tropicalis

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