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Gene Review

RTN2  -  reticulon 2

Homo sapiens

Synonyms: NSP-like protein 1, NSP-like protein I, NSP2, NSPL1, NSPLI, ...
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High impact information on RTN2

  • Like the RTN1 gene, the RTN2 gene is transcribed into different mRNA variants [1].
  • Analysis of the expression of the RTN2 gene shows differential expression in human tissues with a strikingly high expression of the 1.3-kb transcript in skeletal muscle [1].
  • This paper describes the cDNA cloning, genomic organization, and expression of the human RTN2 gene on chromosome 19q13.3, which was recognized by virtue of its high similarity with the human RTN1 (formerly called NSP) gene on chromosome 14q21-q22 [1].
  • Two hydrophobic subregions are present, which are thought to be responsible for the association of the RTN1 and RTN2 proteins with the endoplasmic reticulum [1].
  • In a region of about 12 kb in total, 11 RTN2 exons could be identified [1].

Biological context of RTN2

  • In vitro studies were performed using two plasmid constructs that generate full-length Nspl1 muscle-specific protein fused to the green fluorescent protein (GFP) [2].

Anatomical context of RTN2


Analytical, diagnostic and therapeutic context of RTN2

  • The human gene structure prediction program FGENEH, exon prediction-FEXH and splice site prediction-HSPL have been modified for sequence analysis of Drosophila (FGENED, FEXD and DSPL), C.elegance (FGENEN, FEXN and NSPL), Yeast (FEXY and YSPL) and Plant (FGENEA, FEXA and ASPL) genomic sequences [3].


  1. cDNA cloning, genomic organization, and expression of the human RTN2 gene, a member of a gene family encoding reticulons. Roebroek, A.J., Contreras, B., Pauli, I.G., Van de Ven, W.J. Genomics (1998) [Pubmed]
  2. Nspl1, a new Z-band-associated protein. Geisler, J.G., Palmer, R.J., Stubbs, L.J., Mucenski, M.L. J. Muscle Res. Cell. Motil. (1999) [Pubmed]
  3. The Gene-Finder computer tools for analysis of human and model organisms genome sequences. Solovyev, V., Salamov, A. Proceedings / ... International Conference on Intelligent Systems for Molecular Biology ; ISMB. International Conference on Intelligent Systems for Molecular Biology. (1997) [Pubmed]
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