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Gene Review

LHPP  -  phospholysine phosphohistidine inorganic...

Homo sapiens

Synonyms: HDHD2B, Phospholysine phosphohistidine inorganic pyrophosphate phosphatase, hLHPP
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High impact information on LHPP

  • Structurally, it has been suggested that LHPP consists of a 5:1 ratio of dark-stable ternary complexes of the light-dependent NADPH: protochlorophyllide oxidoreductases A and B containing nonphotoactive protochlorophyllide b and photoactive protochlorophyllide a, respectively [1].
  • We cloned a new human PPase, phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPPase), and established a rabbit polyclonal anti-LHPPase antibody [2].
  • It is nucleus-encoded, imported into the plastids posttranslationally, and assembled into larger light-harvesting POR:protochlorophyllide complexes termed LHPP (Reinbothe et al., Nature 397:80-84, 1999) [3].

Analytical, diagnostic and therapeutic context of LHPP


  1. Does a light-harvesting protochlorophyllide a/b-binding protein complex exist? Armstrong, G.A., Apel, K., Rüdiger, W. Trends Plant Sci. (2000) [Pubmed]
  2. Expression of new human inorganic pyrophosphatase in thyroid diseases: its intimate association with hyperthyroidism. Koike, E., Toda, S., Yokoi, F., Izuhara, K., Koike, N., Itoh, K., Miyazaki, K., Sugihara, H. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  3. In vitro-mutagenesis of NADPH:protochlorophyllide oxidoreductase B: two distinctive protochlorophyllide binding sites participate in enzyme catalysis and assembly. Reinbothe, C., Buhr, F., Bartsch, S., Desvignes, C., Quigley, F., Pesey, H., Reinbothe, S. Mol. Genet. Genomics (2006) [Pubmed]
  4. Molecular cloning of a cDNA for the human phospholysine phosphohistidine inorganic pyrophosphate phosphatase. Yokoi, F., Hiraishi, H., Izuhara, K. J. Biochem. (2003) [Pubmed]
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