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Kcnk13  -  potassium channel, two pore domain...

Rattus norvegicus

Synonyms: Potassium channel subfamily K member 13, THIK-1, Tandem pore domain halothane-inhibited potassium channel 1, prdx1
 
 
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High impact information on Kcnk13

  • This pharmacological profile suggests the O2-sensitive conductance in GPN neurones is mediated by a class of background K+ channels different from the TASK family; it appears more closely related to the THIK (tandem pore domain halothane-inhibited K+) subfamily, or may represent a new member of the background K+ family [1].
  • RT-PCR revealed message for the following AA-sensitive K(2P) channels in rat MCA: tandem of P domains in weak inward rectifier K+ (TWIK-2), TWIK-related K+ (TREK-1 and TREK-2), TWIK-related AA-stimulated K+ (TRAAK), and TWIK-related halothane-inhibited K+ (THIK-1) channels [2].
 

Anatomical context of Kcnk13

References

  1. A novel O2-sensing mechanism in rat glossopharyngeal neurones mediated by a halothane-inhibitable background K+ conductance. Campanucci, V.A., Fearon, I.M., Nurse, C.A. J. Physiol. (Lond.) (2003) [Pubmed]
  2. Evidence for two-pore domain potassium channels in rat cerebral arteries. Bryan, R.M., You, J., Phillips, S.C., Andresen, J.J., Lloyd, E.E., Rogers, P.A., Dryer, S.E., Marrelli, S.P. Am. J. Physiol. Heart Circ. Physiol. (2006) [Pubmed]
  3. Functional evidence of a role for two-pore domain potassium channels in rat mesenteric and pulmonary arteries. Gardener, M.J., Johnson, I.T., Burnham, M.P., Edwards, G., Heagerty, A.M., Weston, A.H. Br. J. Pharmacol. (2004) [Pubmed]
 
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