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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Pulmonary Artery

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Disease relevance of Pulmonary Artery


Psychiatry related information on Pulmonary Artery


High impact information on Pulmonary Artery


Chemical compound and disease context of Pulmonary Artery


Biological context of Pulmonary Artery


Anatomical context of Pulmonary Artery


Associations of Pulmonary Artery with chemical compounds


Gene context of Pulmonary Artery

  • Both approaches indicated a more than twofold reduction in lung water accumulation in AQP1 (-/-) vs. (+/+) mice in response to a 5- to 10-cm H2O increase in pulmonary artery pressure for five minutes [32].
  • Moreover, RP 67580 displayed the profile of a specific antagonist of NK1 receptors: it was not active on NK2 and NK3 receptors as seen in binding assays and in isolated preparations of rabbit pulmonary artery and rat portal vein [33].
  • Using degenerate oligonucleotides and reverse transcriptase-polymerase chain reaction, we have screened bovine microvascular endothelial (BME), aortic, lymphatic, pulmonary artery, and transformed fetal aortic endothelial cells, as well as rat smooth muscle cells for Ang1 and Ang2 expression [34].
  • CBDL pulmonary artery segments had markedly increased ET(B) receptor mediated, nitric oxide dependent vasodilatory responses to ET-1 compared with controls and ET-1 triggered an ET(B) receptor dependent stimulation of eNOS in RPMVECs [35].
  • We also show that Tbx1 expression is required in cells expressing Nkx2.5 for the formation of the aorto-pulmonary septum, which divides the aorta from the main pulmonary artery [36].

Analytical, diagnostic and therapeutic context of Pulmonary Artery


  1. Impairment of endothelium-dependent pulmonary-artery relaxation in chronic obstructive lung disease. Dinh-Xuan, A.T., Higenbottam, T.W., Clelland, C.A., Pepke-Zaba, J., Cremona, G., Butt, A.Y., Large, S.R., Wells, F.C., Wallwork, J. N. Engl. J. Med. (1991) [Pubmed]
  2. High-dose corticosteroids in patients with the adult respiratory distress syndrome. Bernard, G.R., Luce, J.M., Sprung, C.L., Rinaldo, J.E., Tate, R.M., Sibbald, W.J., Kariman, K., Higgins, S., Bradley, R., Metz, C.A. N. Engl. J. Med. (1987) [Pubmed]
  3. Septic endocarditis and indwelling pulmonary artery catheters. Greene, J.F., Fitzwater, J.E., Clemmer, T.P. JAMA (1975) [Pubmed]
  4. The Washington University-Barnes Hospital experience with lung transplantation. Washington University Lung Transplantation Group. Trulock, E.P., Cooper, J.D., Kaiser, L.R., Pasque, M.K., Ettinger, N.A., Dresler, C.M. JAMA (1991) [Pubmed]
  5. Prostacyclin production and mediation of adenylate cyclase activity in the pulmonary artery. Alterations after prolonged hypoxia in the rat. Shaul, P.W., Kinane, B., Farrar, M.A., Buja, L.M., Magness, R.R. J. Clin. Invest. (1991) [Pubmed]
  6. RhoA/Rho kinase and nitric oxide modulate the agonist-induced pulmonary artery diameter response time. Boer, C., van der Linden, P.J., Scheffer, G.J., Westerhof, N., de Lange, J.J., Sipkema, P. Am. J. Physiol. Heart Circ. Physiol. (2002) [Pubmed]
  7. Clinical and molecular genetic features of pulmonary hypertension in patients with hereditary hemorrhagic telangiectasia. Trembath, R.C., Thomson, J.R., Machado, R.D., Morgan, N.V., Atkinson, C., Winship, I., Simonneau, G., Galie, N., Loyd, J.E., Humbert, M., Nichols, W.C., Morrell, N.W., Berg, J., Manes, A., McGaughran, J., Pauciulo, M., Wheeler, L. N. Engl. J. Med. (2001) [Pubmed]
  8. Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension. The International PPH Consortium. Lane, K.B., Machado, R.D., Pauciulo, M.W., Thomson, J.R., Phillips, J.A., Loyd, J.E., Nichols, W.C., Trembath, R.C. Nat. Genet. (2000) [Pubmed]
  9. Inhaled nitric oxide for the adult respiratory distress syndrome. Rossaint, R., Falke, K.J., López, F., Slama, K., Pison, U., Zapol, W.M. N. Engl. J. Med. (1993) [Pubmed]
  10. Heparin bonding reduces thrombogenicity of pulmonary-artery catheters. Hoar, P.F., Wilson, R.M., Mangano, D.T., Avery, G.J., Szarnicki, R.J., Hill, J.D. N. Engl. J. Med. (1981) [Pubmed]
  11. Pulmonary hypertension in severe acute respiratory failure. Zapol, W.M., Snider, M.T. N. Engl. J. Med. (1977) [Pubmed]
  12. Control of cardiac output in thyrotoxic calves. Evaluation of changes in the systemic circulation. Goldman, S., Olajos, M., Morkin, E. J. Clin. Invest. (1984) [Pubmed]
  13. Acetyl glyceryl ether phosphorylcholine-stimulated human platelets cause pulmonary hypertension and edema in isolated rabbit lungs. Role of thromboxane A2. Heffner, J.E., Shoemaker, S.A., Canham, E.M., Patel, M., McMurtry, I.F., Morris, H.G., Repine, J.E. J. Clin. Invest. (1983) [Pubmed]
  14. Angiotensin converting enzyme expression is increased in small pulmonary arteries of rats with hypoxia-induced pulmonary hypertension. Morrell, N.W., Atochina, E.N., Morris, K.G., Danilov, S.M., Stenmark, K.R. J. Clin. Invest. (1995) [Pubmed]
  15. Human platelets modulate edema formation in isolated rabbit lungs. Heffner, J.E., Cook, J.A., Halushka, P.V. J. Clin. Invest. (1989) [Pubmed]
  16. Primary pulmonary hypertension treated with oral phentolamine. Ruskin, J.N., Hutter, A.M. Ann. Intern. Med. (1979) [Pubmed]
  17. Images in clinical medicine. Dilatation of the pulmonary arteries in primary pulmonary hypertension. Lang, I.M., Kneussl, M.P. N. Engl. J. Med. (1996) [Pubmed]
  18. Complete reversal of fatal pulmonary hypertension in rats by a serine elastase inhibitor. Cowan, K.N., Heilbut, A., Humpl, T., Lam, C., Ito, S., Rabinovitch, M. Nat. Med. (2000) [Pubmed]
  19. Hydroxyproline and passive stiffness of pressure-induced hypertrophied kitten myocardium. Williams, J.F., Potter, R.D., Hern, D.L., Mathew, B., Deiss, W.P. J. Clin. Invest. (1982) [Pubmed]
  20. Hypoxia-induced increases in pulmonary transvascular protein escape in rats. Modulation by glucocorticoids. Stelzner, T.J., O'Brien, R.F., Sato, K., Weil, J.V. J. Clin. Invest. (1988) [Pubmed]
  21. Prostacyclin synthesis in ovine pulmonary artery is developmentally regulated by changes in cyclooxygenase-1 gene expression. Brannon, T.S., North, A.J., Wells, L.B., Shaul, P.W. J. Clin. Invest. (1994) [Pubmed]
  22. Adenosine diphosphate-ribosylation of G-actin by botulinum C2 toxin increases endothelial permeability in vitro. Suttorp, N., Polley, M., Seybold, J., Schnittler, H., Seeger, W., Grimminger, F., Aktories, K. J. Clin. Invest. (1991) [Pubmed]
  23. Prolonged endothelin A receptor blockade attenuates chronic pulmonary hypertension in the ovine fetus. Ivy, D.D., Parker, T.A., Ziegler, J.W., Galan, H.L., Kinsella, J.P., Tuder, R.M., Abman, S.H. J. Clin. Invest. (1997) [Pubmed]
  24. Long-term sympathetic and hemodynamic responses to clonidine in patients with cirrhosis and ascites. Roulot, D., Moreau, R., Gaudin, C., Bacq, Y., Braillon, A., Hadengue, A., Frohly, P., Lebrec, D. Gastroenterology (1992) [Pubmed]
  25. Kv2.1/Kv9.3, a novel ATP-dependent delayed-rectifier K+ channel in oxygen-sensitive pulmonary artery myocytes. Patel, A.J., Lazdunski, M., Honoré, E. EMBO J. (1997) [Pubmed]
  26. Noninvasive determination of coronary artery bypass graft patency by cine magnetic resonance imaging. Aurigemma, G.P., Reichek, N., Axel, L., Schiebler, M., Harris, C., Kressel, H.Y. Circulation (1989) [Pubmed]
  27. Endotoxin "priming" potentiates lung vascular abnormalities in response to Escherichia coli hemolysin: an example of synergism between endo- and exotoxin. Walmrath, D., Ghofrani, H.A., Rosseau, S., Schütte, H., Cramer, A., Kaddus, W., Grimminger, F., Bhakdi, S., Seeger, W. J. Exp. Med. (1994) [Pubmed]
  28. Aggregating platelets contract isolated canine pulmonary arteries by releasing 5-hydroxytryptamine. McGoon, M.D., Vanhoutte, P.M. J. Clin. Invest. (1984) [Pubmed]
  29. Regulation of bovine endothelial constitutive nitric oxide synthase by oxygen. Liao, J.K., Zulueta, J.J., Yu, F.S., Peng, H.B., Cote, C.G., Hassoun, P.M. J. Clin. Invest. (1995) [Pubmed]
  30. Persistence of the fetal pattern of tropoelastin gene expression in severe neonatal bovine pulmonary hypertension. Stenmark, K.R., Durmowicz, A.G., Roby, J.D., Mecham, R.P., Parks, W.C. J. Clin. Invest. (1994) [Pubmed]
  31. Nitric oxide decreases stability of mRNAs encoding soluble guanylate cyclase subunits in rat pulmonary artery smooth muscle cells. Filippov, G., Bloch, D.B., Bloch, K.D. J. Clin. Invest. (1997) [Pubmed]
  32. Lung fluid transport in aquaporin-1 and aquaporin-4 knockout mice. Bai, C., Fukuda, N., Song, Y., Ma, T., Matthay, M.A., Verkman, A.S. J. Clin. Invest. (1999) [Pubmed]
  33. Pharmacological properties of a potent and selective nonpeptide substance P antagonist. Garret, C., Carruette, A., Fardin, V., Moussaoui, S., Peyronel, J.F., Blanchard, J.C., Laduron, P.M. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  34. Regulation of angiopoietin-2 mRNA levels in bovine microvascular endothelial cells by cytokines and hypoxia. Mandriota, S.J., Pepper, M.S. Circ. Res. (1998) [Pubmed]
  35. The role of endothelin-1 and the endothelin B receptor in the pathogenesis of hepatopulmonary syndrome in the rat. Ling, Y., Zhang, J., Luo, B., Song, D., Liu, L., Tang, L., Stockard, C.R., Grizzle, W.E., Ku, D.D., Fallon, M.B. Hepatology (2004) [Pubmed]
  36. Tbx1 has a dual role in the morphogenesis of the cardiac outflow tract. Xu, H., Morishima, M., Wylie, J.N., Schwartz, R.J., Bruneau, B.G., Lindsay, E.A., Baldini, A. Development (2004) [Pubmed]
  37. Plasma and lipids from stored packed red blood cells cause acute lung injury in an animal model. Silliman, C.C., Voelkel, N.F., Allard, J.D., Elzi, D.J., Tuder, R.M., Johnson, J.L., Ambruso, D.R. J. Clin. Invest. (1998) [Pubmed]
  38. Transforming growth factor-beta 1 is decreased in remodeling hypertensive bovine pulmonary arteries. Botney, M.D., Parks, W.C., Crouch, E.C., Stenmark, K., Mecham, R.P. J. Clin. Invest. (1992) [Pubmed]
  39. Protection of rabbit lungs from endotoxin injury by in vivo hyperexpression of the prostaglandin G/H synthase gene. Conary, J.T., Parker, R.E., Christman, B.W., Faulks, R.D., King, G.A., Meyrick, B.O., Brigham, K.L. J. Clin. Invest. (1994) [Pubmed]
  40. Correlation of mean pulmonary artery wedge pressure, left atrial dimention, and PTF-V1 in patients with acute myocardial infarction. Orlando, J., Del Vicario, M., Aronow, W.S., Cassidy, J. Circulation (1977) [Pubmed]
  41. The extraction of circulating catecholamines by the lungs in normal man and in patients with pulmonary hypertension. Sole, M.J., Drobac, M., Schwartz, L., Hussain, M.N., Vaughan-Neil, E.F. Circulation (1979) [Pubmed]
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