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Gene Review

SETMAR  -  SET domain and mariner transposase fusion...

Homo sapiens

Synonyms: Histone-lysine N-methyltransferase SETMAR, HsMar1, METNASE, Mar1, Metnase, ...
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High impact information on SETMAR

  • The presence of these transposons in the human genome constitutes a potential reservoir of approximately 1,500 perfect or nearly perfect SETMAR-binding sites [1].
  • Although SETMAR has demonstrated methylase activity and a DNA repair phenotype, its mode of action and the role of the transposase domain remain obscure [2].
  • Despite this problem, SETMAR retains robust activity for the other stages of the Hsmar1 transposition reaction, namely, site-specific DNA binding to the transposon ends, assembly of a paired-ends complex, cleavage of the 5' end of the element in Mn(2+), and integration at a TA dinucleotide target site [2].

Co-localisations of SETMAR


  1. Birth of a chimeric primate gene by capture of the transposase gene from a mobile element. Cordaux, R., Udit, S., Batzer, M.A., Feschotte, C. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  2. The human SETMAR protein preserves most of the activities of the ancestral Hsmar1 transposase. Liu, D., Bischerour, J., Siddique, A., Buisine, N., Bigot, Y., Chalmers, R. Mol. Cell. Biol. (2007) [Pubmed]
  3. Human Pso4 is a metnase (SETMAR)-binding partner that regulates metnase function in DNA repair. Beck, B.D., Park, S.J., Lee, Y.J., Roman, Y., Hromas, R.A., Lee, S.H. J. Biol. Chem. (2008) [Pubmed]
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