Gene Review:
PRPF19 - pre-mRNA processing factor 19
Homo sapiens
Synonyms:
NMP200, Nuclear matrix protein 200, PRP19, PRP19/PSO4 homolog, PSO4, ...
- A subset of human 35S U5 proteins, including Prp19, function prior to catalytic step 1 of splicing. Makarova, O.V., Makarov, E.M., Urlaub, H., Will, C.L., Gentzel, M., Wilm, M., Lührmann, R. EMBO J. (2004)
- Role of human Pso4 in mammalian DNA repair and association with terminal deoxynucleotidyl transferase. Mahajan, K.N., Mitchell, B.S. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Structural insights into the U-box, a domain associated with multi-ubiquitination. Ohi, M.D., Vander Kooi, C.W., Rosenberg, J.A., Chazin, W.J., Gould, K.L. Nat. Struct. Biol. (2003)
- Structural insights into the U-box, a domain associated with multi-ubiquitination. Ohi, M.D., Vander Kooi, C.W., Rosenberg, J.A., Chazin, W.J., Gould, K.L. Nat. Struct. Biol. (2003)
- Early embryonic lethality of mice lacking the essential protein SNEV. Fortschegger, K., Wagner, B., Voglauer, R., Katinger, H., Sibilia, M., Grillari, J. Mol. Cell. Biol. (2007)
- SNEV overexpression extends the life span of human endothelial cells. Voglauer, R., Chang, M.W., Dampier, B., Wieser, M., Baumann, K., Sterovsky, T., Schreiber, M., Katinger, H., Grillari, J. Exp. Cell. Res. (2006)
- The Pso4 mRNA splicing and DNA repair complex interacts with WRN for processing of DNA interstrand cross-links. Zhang, N., Kaur, R., Lu, X., Shen, X., Li, L., Legerski, R.J. J. Biol. Chem. (2005)
- hNMP 200: a novel human common nuclear matrix protein combining structural and regulatory functions. Gotzmann, J., Gerner, C., Meissner, M., Holzmann, K., Grimm, R., Mikulits, W., Sauermann, G. Exp. Cell Res. (2000)
- SNEV is an evolutionarily conserved splicing factor whose oligomerization is necessary for spliceosome assembly. Grillari, J., Ajuh, P., Stadler, G., Löscher, M., Voglauer, R., Ernst, W., Chusainow, J., Eisenhaber, F., Pokar, M., Fortschegger, K., Grey, M., Lamond, A.I., Katinger, H. Nucleic Acids Res. (2005)
- Proteome analysis of nuclear matrix proteins during apoptotic chromatin condensation. Gerner, C., Gotzmann, J., Fröhwein, U., Schamberger, C., Ellinger, A., Sauermann, G. Cell Death Differ. (2002)
- U box proteins as a new family of ubiquitin-protein ligases. Hatakeyama, S., Yada, M., Matsumoto, M., Ishida, N., Nakayama, K.I. J. Biol. Chem. (2001)
- Interaction of U-box E3 ligase SNEV with PSMB4, the beta7 subunit of the 20 S proteasome. Löscher, M., Fortschegger, K., Ritter, G., Wostry, M., Voglauer, R., Schmid, J.A., Watters, S., Rivett, A.J., Ajuh, P., Lamond, A.I., Katinger, H., Grillari, J. Biochem. J. (2005)
- Haploinsufficiency of senescence evasion factor causes defects of hematopoietic stem cells functions. Schraml, E., Voglauer, R., Fortschegger, K., Sibilia, M., Stelzer, I., Grillari, J., Schauenstein, K. Stem. Cells. Dev. (2008)
- Differential segregation and modification of mRNA during spermiogenesis in Marsilea vestita. Tsai, C.W., Van Der Weele, C.M., Wolniak, S.M. Dev. Biol. (2004)
- Blom7alpha is a novel heterogeneous nuclear ribonucleoprotein K homology domain protein involved in pre-mRNA splicing that interacts with SNEVPrp19-Pso4. Grillari, J., Löscher, M., Denegri, M., Lee, K., Fortschegger, K., Eisenhaber, F., Ajuh, P., Lamond, A.I., Katinger, H., Grillari-Voglauer, R. J. Biol. Chem. (2009)
- The Prp19 U-box crystal structure suggests a common dimeric architecture for a class of oligomeric E3 ubiquitin ligases. Vander Kooi, C.W., Ohi, M.D., Rosenberg, J.A., Oldham, M.L., Newcomer, M.E., Gould, K.L., Chazin, W.J. Biochemistry (2006)