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Metap2  -  methionyl aminopeptidase 2

Rattus norvegicus

Synonyms: Amp2, Initiation factor 2-associated 67 kDa glycoprotein, MAP 2, MetAP 2, Methionine aminopeptidase 2, ...
 
 
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High impact information on Metap2

  • Negative regulation of the protection of eIF2alpha phosphorylation activity by a unique acidic domain present at the N-terminus of p67 [1].
  • Individual alanine substitutions at the above conserved amino acids in wild-type p67 did not show any significant effect on POEP activity except the E459 position where alanine substitution caused approximately 50% increase in POEP activity as compared to the wild type [1].
  • Discovery and optimization of anthranilic acid sulfonamides as inhibitors of methionine aminopeptidase-2: a structural basis for the reduction of albumin binding [2].

References

  1. Negative regulation of the protection of eIF2alpha phosphorylation activity by a unique acidic domain present at the N-terminus of p67. Datta, R., Tammali, R., Datta, B. Exp. Cell Res. (2003) [Pubmed]
  2. Discovery and optimization of anthranilic acid sulfonamides as inhibitors of methionine aminopeptidase-2: a structural basis for the reduction of albumin binding. Sheppard, G.S., Wang, J., Kawai, M., Fidanze, S.D., BaMaung, N.Y., Erickson, S.A., Barnes, D.M., Tedrow, J.S., Kolaczkowski, L., Vasudevan, A., Park, D.C., Wang, G.T., Sanders, W.J., Mantei, R.A., Palazzo, F., Tucker-Garcia, L., Lou, P., Zhang, Q., Park, C.H., Kim, K.H., Petros, A., Olejniczak, E., Nettesheim, D., Hajduk, P., Henkin, J., Lesniewski, R., Davidsen, S.K., Bell, R.L. J. Med. Chem. (2006) [Pubmed]
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