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Gene Review

MAP2  -  Map2p

Saccharomyces cerevisiae S288c

Synonyms: MAP 2, MetAP 2, Methionine aminopeptidase 2, Peptidase M, YBL0701, ...
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Disease relevance of MAP2

  • Angiogenesis inhibitors specific for methionine aminopeptidase 2 as drugs for malaria and leishmaniasis [1].

High impact information on MAP2


Biological context of MAP2


Anatomical context of MAP2

  • In neurones, a limited number of mRNAs is found in dendrites, including transcripts encoding the microtubule-associated protein 2 (MAP2) [8].
  • The purified enzyme also used a number of mammalian proteins as phosphoacceptors, including myelin basic protein (MBP), microtubule-associated protein 2 (MAP-2), and tau protein [9].

Associations of MAP2 with chemical compounds

  • Eukaryotic methionine aminopeptidase type 2 (MetAP2, MetAP2 gene (MAP2)), together with eukaryotic MetAP1, cotranslationally hydrolyzes initiator methionine from nascent polypeptides when the side chain of the second residue is small and uncharged [10].
  • Hence, these results identify MetAP-2 as an important target of study in the analysis of the potent biological activities of fumagillin [3].
  • Some of the pyridine-2-carboxylic acid derivatives (compound 2 and 3) had selective inhibition of the growth of map2 deletion yeast and weak inhibition on wild-type yeast growth, while no inhibition on map1 deletion yeast [11].


  1. Angiogenesis inhibitors specific for methionine aminopeptidase 2 as drugs for malaria and leishmaniasis. Zhang, P., Nicholson, D.E., Bujnicki, J.M., Su, X., Brendle, J.J., Ferdig, M., Kyle, D.E., Milhous, W.K., Chiang, P.K. J. Biomed. Sci. (2002) [Pubmed]
  2. Fission yeast genes that confer resistance to staurosporine encode an AP-1-like transcription factor and a protein kinase related to the mammalian ERK1/MAP2 and budding yeast FUS3 and KSS1 kinases. Toda, T., Shimanuki, M., Yanagida, M. Genes Dev. (1991) [Pubmed]
  3. The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAP-2. Sin, N., Meng, L., Wang, M.Q., Wen, J.J., Bornmann, W.G., Crews, C.M. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  4. Amino-terminal protein processing in Saccharomyces cerevisiae is an essential function that requires two distinct methionine aminopeptidases. Li, X., Chang, Y.H. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  5. A single amino acid residue defines the difference in ovalicin sensitivity between type I and II methionine aminopeptidases. Brdlik, C.M., Crews, C.M. J. Biol. Chem. (2004) [Pubmed]
  6. Phylogenetic relationships of methionine aminopeptidase 2 among Encephalitozoon species and genotypes of microsporidia. Pandrea, I., Mittleider, D., Brindley, P.J., Didier, E.S., Robertson, D.L. Mol. Biochem. Parasitol. (2005) [Pubmed]
  7. Methionine aminopeptidases type I and type II are essential to control cell proliferation. Bernier, S.G., Taghizadeh, N., Thompson, C.D., Westlin, W.F., Hannig, G. J. Cell. Biochem. (2005) [Pubmed]
  8. Two rat brain staufen isoforms differentially bind RNA. Monshausen, M., Putz, U., Rehbein, M., Schweizer, M., DesGroseillers, L., Kuhl, D., Richter, D., Kindler, S. J. Neurochem. (2001) [Pubmed]
  9. Yeast MCK1 protein kinase autophosphorylates at tyrosine and serine but phosphorylates exogenous substrates at serine and threonine. Lim, M.Y., Dailey, D., Martin, G.S., Thorner, J. J. Biol. Chem. (1993) [Pubmed]
  10. Evidence of a dominant negative mutant of yeast methionine aminopeptidase type 2 in Saccharomyces cerevisiae. Vetro, J.A., Dummitt, B., Micka, W.S., Chang, Y.H. J. Cell. Biochem. (2005) [Pubmed]
  11. Type I methionine aminopeptidase from Saccharomyces cerevisiae is a potential target for antifungal drug screening. Chen, L.L., Li, J., Li, J.Y., Luo, Q.L., Mao, W.F., Shen, Q., Nan, F.J., Ye, Q.Z. Acta Pharmacol. Sin. (2004) [Pubmed]
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