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Hsf2  -  heat shock transcription factor 2

Rattus norvegicus

 
 
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High impact information on Hsf2

  • Stage-specific expression and cellular localization of the heat shock factor 2 isoforms in the rat seminiferous epithelium [1].
  • Results show that the major transcription initiation site of the Hsf2 gene is located at cytosine-155 relative to the translation initiation site [2].
  • Cloning and characterization of the rat Hsf2 promoter: a critical role of proximal E-box element and USF protein in Hsf2 regulation in different compartments of the brain [2].
  • The E-box element located immediate upstream of the transcription initiation site was demonstrated to be critical for Hsf2 promoter activity, and the upstream stimulatory factor (USF) protein was identified as the major E-box binding protein [2].
  • The presence of several transcription factor binding sites of biological importance in the Hsf2 promoter suggests that identifying the interplay of USF and these factors should help further elucidate the molecular mechanisms of tissue-, cell type- and developmental stage-specific expression of Hsf2 [2].

References

  1. Stage-specific expression and cellular localization of the heat shock factor 2 isoforms in the rat seminiferous epithelium. Alastalo, T.P., Lönnström, M., Leppä, S., Kaarniranta, K., Pelto-Huikko, M., Sistonen, L., Parvinen, M. Exp. Cell Res. (1998) [Pubmed]
  2. Cloning and characterization of the rat Hsf2 promoter: a critical role of proximal E-box element and USF protein in Hsf2 regulation in different compartments of the brain. Lee, S.S., Kwon, S.H., Sung, J.S., Han, M.Y., Park, Y.M. Biochim. Biophys. Acta (2003) [Pubmed]
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