Disease relevance of Seminiferous Epithelium

• The massive hyperplasia that occurs in Bax-deficient mice subsequently results in Bax independent cell death that may be triggered by overcrowding of the seminiferous epithelium [1].
• Testicular toxicity of methylmercury: analysis of cellular distribution pattern at different stages of the seminiferous epithelium [2].
• OBJECTIVE: Analyze the changes in the seminiferous epithelium in rats with carbon tetrachloride-induced cirrhosis (CCl4) [3].

High impact information on Seminiferous Epithelium

• CFTR expression is regulated during both the cycle of the seminiferous epithelium and the oestrous cycle of rodents [4].
• In the testis, CFTR expression is regulated during the cycle of the seminiferous epithelium [5].
• In normal mice, the PDGF-A and PDGF-Ralpha expression pattern showed positive cells in the seminiferous epithelium and in interstitial mesenchymal cells, respectively [6].
• Microtubules in the cytoplasm of rat Sertoli cell stage VI-VIII testicular seminiferous epithelium were studied morphometrically by electron microscopy [7].
• Localization of protamine 1 mRNA in different stages of the cycle of the rat seminiferous epithelium [8].

Biological context of Seminiferous Epithelium

• GATA-1 is an essential factor for the transcriptional activation of erythroid-specific genes, and is also abundantly expressed in a discrete subset of cells bordering the seminiferous epithelium in tubules of the murine testis [9].
• In BM of adult seminiferous epithelium with active spermatogenesis, immunoreactivity for Ln beta 2- and gamma 1-chains was found but not for Ln alpha-chains, suggesting a complex of Ln chains not compatible with any known trimers [10].
• These results suggest that testins are unique testicular proteins that can be used to study Sertoli cell-germ cell interactions in the seminiferous epithelium [11].
• Regulation of urokinase- and tissue-type plasminogen activator gene expression in the rat seminiferous epithelium [12].
• CONCLUSION: These data suggest that some radionuclides may access the seminiferous epithelium through receptor-mediated endocytosis of transferrin [13].

Anatomical context of Seminiferous Epithelium

• These results suggest that androgen action in Sertoli cells regulates germ cell differentiation, in part by controlling the microenvironment of the seminiferous epithelium [14].
• Cells responsible for the synthesis of ChAT mRNA in rat testis were localized by in situ hybridization in the middle part of the seminiferous epithelium, where the labeling was mostly found over spermatocytes and spermatids [15].
• We have shown previously that POMC mRNAs are most abundant in a subpopulation of Leydig cells associated with tubules in specific stages of the cycle of the seminiferous epithelium [16].
• Observations in Ar hypomorphic animals demonstrate that terminal differentiation of spermatids and their release from the seminiferous epithelium is AR dependent and maximally sensitive to AR depletion within the testis [17].
• Among the subunits of Ln-binding Int receptors in fetal seminiferous tubules, a strong immunoreactivity for Int beta 1- and Int alpha 6-subunits was seen throughout the seminiferous epithelium, other Int subunits being found in interstitial cells [10].

Associations of Seminiferous Epithelium with chemical compounds

• Despite the demonstration of the aromatase enzyme, which converts androgens to estrogens, and estrogen receptors within the rodent seminiferous epithelium, the role of aromatase and estrogen in germ cell development is unknown [18].
• Several recent morphological studies in various mammals have suggested that partial protection of the seminiferous epithelium against cancer therapeutic agents could be obtained by treatments using gonadotropin-releasing hormone analogues or steroids [19].
• Regulation of ectoplasmic specialization dynamics in the seminiferous epithelium by focal adhesion-associated proteins in testosterone-suppressed rat testes [20].
• Stage and cell-specific expression of the adenosine 3',5' monophosphate-phosphodiesterase genes in the rat seminiferous epithelium [21].
• Adjudin-mediated junction restructuring in the seminiferous epithelium leads to displacement of soluble guanylate cyclase from adherens junctions [22].

Gene context of Seminiferous Epithelium

• TNF-alpha and IFN-gamma regulate expression and function of the Fas system in the seminiferous epithelium [23].
• Using fluorescent microscopy with dual fluorescent probes, IQGAP1 was found to co-localize, at least in part, with N-cadherin in the seminiferous epithelium consistent with their localization at the basal and apical ES [24].
• Expression of inhibin beta A and beta B, follistatin and activin-A receptor messenger ribonucleic acids in the rat seminiferous epithelium [25].
• After initiation of stage synchrony of spermatogenesis, increased testicular concentrations of epidermal growth factor (EGF) were observed in testes synchronized between stages IX-II than at other stages of the cycle of the seminiferous epithelium [26].
• PRL-R mRNA was expressed in all stages of the cycle of the seminiferous epithelium [27].

Analytical, diagnostic and therapeutic context of Seminiferous Epithelium

• Northern blot analysis of mRNAs from testes of rats synchronized at various stages of the cycle of the seminiferous epithelium showed that transferrin receptor mRNA was differentially regulated throughout the cycle [28].
• Vasectomy destroyed the seminiferous epithelium but did not impair renin-like immunoreactivity of the interstitial tissue [29].
• Studies using immunohistochemistry suggested that testin is a component of the specialized junctional complexes in the seminiferous epithelium and other tissues [30].
• In immunoprecipitation experiments on both seminiferous epithelium explants and Sertoli cell cultures from 3-wk-old rats, anti-alpha 6A antibody coprecipitates a polypeptide of 118 kDa, presumably corresponding to beta 1 chain [31].
• To find out the local regulation of inhibin production and its possible paracrine role in the seminiferous epithelium, inhibin alpha mRNA levels were measured in sequential 1 mm segments of rat seminiferous tubules accurately staged by transillumination technique [32].

References