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MeSH Review

E-Box Elements

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Disease relevance of E-Box Elements


High impact information on E-Box Elements


Biological context of E-Box Elements


Anatomical context of E-Box Elements


Associations of E-Box Elements with chemical compounds


Gene context of E-Box Elements

  • Indeed, Stat1 and USF-1 bind to the GAS/E box motif in a cooperative manner [24].
  • Mnt and Myc require interaction with Max for specific DNA binding at E-box sites, but have opposing transcriptional activities [25].
  • The function of these proteins as transcription factors is mediated by heterodimerization with the small bHLHZip protein Max, which is required for their specific DNA binding to E-box sequences [26].
  • Both promoters contain a consensus E-box motif that mediates the regulation of the PPARgamma gene by ADD-1/SREBP-1 and SREBP-2 [27].
  • USF1 and 2 bound to the E-box motif in the TME and strongly transactivated the PF4 promoter [16].

Analytical, diagnostic and therapeutic context of E-Box Elements


  1. Cloning of an inr- and E-box-binding protein, TFII-I, that interacts physically and functionally with USF1. Roy, A.L., Du, H., Gregor, P.D., Novina, C.D., Martinez, E., Roeder, R.G. EMBO J. (1997) [Pubmed]
  2. Genome-wide analysis of gene expression associated with MYCN in human neuroblastoma. Alaminos, M., Mora, J., Cheung, N.K., Smith, A., Qin, J., Chen, L., Gerald, W.L. Cancer Res. (2003) [Pubmed]
  3. Glucose catabolism in cancer cells: identification and characterization of a marked activation response of the type II hexokinase gene to hypoxic conditions. Mathupala, S.P., Rempel, A., Pedersen, P.L. J. Biol. Chem. (2001) [Pubmed]
  4. Interactions of HTF4 with E-box motifs in the long terminal repeat of human immunodeficiency virus type 1. Zhang, Y., Doyle, K., Bina, M. J. Virol. (1992) [Pubmed]
  5. Rhythmic CLOCK-BMAL1 binding to multiple E-box motifs drives circadian Dbp transcription and chromatin transitions. Ripperger, J.A., Schibler, U. Nat. Genet. (2006) [Pubmed]
  6. Dec1 and Dec2 are regulators of the mammalian molecular clock. Honma, S., Kawamoto, T., Takagi, Y., Fujimoto, K., Sato, F., Noshiro, M., Kato, Y., Honma, K. Nature (2002) [Pubmed]
  7. Methylation-sensitive sequence-specific DNA binding by the c-Myc basic region. Prendergast, G.C., Ziff, E.B. Science (1991) [Pubmed]
  8. Transactivation-defective c-MycS retains the ability to regulate proliferation and apoptosis. Xiao, Q., Claassen, G., Shi, J., Adachi, S., Sedivy, J., Hann, S.R. Genes Dev. (1998) [Pubmed]
  9. Discrimination between different E-box-binding proteins at an endogenous target gene of c-myc. Desbarats, L., Gaubatz, S., Eilers, M. Genes Dev. (1996) [Pubmed]
  10. CLOCK, an essential pacemaker component, controls expression of the circadian transcription factor DBP. Ripperger, J.A., Shearman, L.P., Reppert, S.M., Schibler, U. Genes Dev. (2000) [Pubmed]
  11. Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1. Kim, J.B., Sarraf, P., Wright, M., Yao, K.M., Mueller, E., Solanes, G., Lowell, B.B., Spiegelman, B.M. J. Clin. Invest. (1998) [Pubmed]
  12. TGF-beta-activated Smad3 represses MEF2-dependent transcription in myogenic differentiation. Liu, D., Kang, J.S., Derynck, R. EMBO J. (2004) [Pubmed]
  13. The GATA-E box-GATA motif in the EKLF promoter is required for in vivo expression. Anderson, K.P., Crable, S.C., Lingrel, J.B. Blood (2000) [Pubmed]
  14. Activation of the mitogen-activated protein kinase pathway induces transcription of the PAC-1 phosphatase gene. Grumont, R.J., Rasko, J.E., Strasser, A., Gerondakis, S. Mol. Cell. Biol. (1996) [Pubmed]
  15. Dual DNA binding specificity of ADD1/SREBP1 controlled by a single amino acid in the basic helix-loop-helix domain. Kim, J.B., Spotts, G.D., Halvorsen, Y.D., Shih, H.M., Ellenberger, T., Towle, H.C., Spiegelman, B.M. Mol. Cell. Biol. (1995) [Pubmed]
  16. Upstream stimulatory factors stimulate transcription through E-box motifs in the PF4 gene in megakaryocytes. Okada, Y., Matsuura, E., Tozuka, Z., Nagai, R., Watanabe, A., Matsumoto, K., Yasui, K., Jackman, R.W., Nakano, T., Doi, T. Blood (2004) [Pubmed]
  17. E47, IRF-4, and PU.1 synergize to induce B-cell-specific activation of the class II transactivator promoter III (CIITA-PIII). van der Stoep, N., Quinten, E., Marcondes Rezende, M., van den Elsen, P.J. Blood (2004) [Pubmed]
  18. Role of upstream stimulatory factor phosphorylation in the regulation of the prostaglandin G/H synthase-2 promoter in granulosa cells. Sayasith, K., Lussier, J.G., Sirois, J. J. Biol. Chem. (2005) [Pubmed]
  19. Definition of regulatory sequence elements in the promoter region and the first intron of the myotonic dystrophy protein kinase gene. Storbeck, C.J., Sabourin, L.A., Waring, J.D., Korneluk, R.G. J. Biol. Chem. (1998) [Pubmed]
  20. Crystal structure of PHO4 bHLH domain-DNA complex: flanking base recognition. Shimizu, T., Toumoto, A., Ihara, K., Shimizu, M., Kyogoku, Y., Ogawa, N., Oshima, Y., Hakoshima, T. EMBO J. (1997) [Pubmed]
  21. Two new members of the emerging KDWK family of combinatorial transcription modulators bind as a heterodimer to flexibly spaced PuCGPy half-sites. Christensen, J., Cotmore, S.F., Tattersall, P. Mol. Cell. Biol. (1999) [Pubmed]
  22. Glucose regulation of mouse S(14) gene expression in hepatocytes. Involvement of a novel transcription factor complex. Koo, S.H., Towle, H.C. J. Biol. Chem. (2000) [Pubmed]
  23. Muscle gene E-box control elements. Evidence for quantitatively different transcriptional activities and the binding of distinct regulatory factors. Apone, S., Hauschka, S.D. J. Biol. Chem. (1995) [Pubmed]
  24. Activation of the MHC class II transactivator CIITA by interferon-gamma requires cooperative interaction between Stat1 and USF-1. Muhlethaler-Mottet, A., Di Berardino, W., Otten, L.A., Mach, B. Immunity (1998) [Pubmed]
  25. Mnt-Max to Myc-Max complex switching regulates cell cycle entry. Walker, W., Zhou, Z.Q., Ota, S., Wynshaw-Boris, A., Hurlin, P.J. J. Cell Biol. (2005) [Pubmed]
  26. Mga, a dual-specificity transcription factor that interacts with Max and contains a T-domain DNA-binding motif. Hurlin, P.J., Steingrìmsson, E., Copeland, N.G., Jenkins, N.A., Eisenman, R.N. EMBO J. (1999) [Pubmed]
  27. Regulation of peroxisome proliferator-activated receptor gamma expression by adipocyte differentiation and determination factor 1/sterol regulatory element binding protein 1: implications for adipocyte differentiation and metabolism. Fajas, L., Schoonjans, K., Gelman, L., Kim, J.B., Najib, J., Martin, G., Fruchart, J.C., Briggs, M., Spiegelman, B.M., Auwerx, J. Mol. Cell. Biol. (1999) [Pubmed]
  28. The myostatin gene is a downstream target gene of basic helix-loop-helix transcription factor MyoD. Spiller, M.P., Kambadur, R., Jeanplong, F., Thomas, M., Martyn, J.K., Bass, J.J., Sharma, M. Mol. Cell. Biol. (2002) [Pubmed]
  29. Characterization of the human lung CYP2F1 gene and identification of a novel lung-specific binding motif. Carr, B.A., Wan, J., Hines, R.N., Yost, G.S. J. Biol. Chem. (2003) [Pubmed]
  30. Transcriptional repression of the human p53 gene by hepatitis B viral X protein. Lee, S.G., Rho, H.M. Oncogene (2000) [Pubmed]
  31. Upstream stimulatory factor regulates E box-dependent PAI-1 transcription in human epidermal keratinocytes. Allen, R.R., Qi, L., Higgins, P.J. J. Cell. Physiol. (2005) [Pubmed]
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