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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Rem2  -  RAS (RAD and GEM) like GTP binding 2

Rattus norvegicus

Synonyms: GTP-binding protein REM 2, Rad and Gem-like GTP-binding protein 2
 
 
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Disease relevance of Rem2

  • Here, we examined the ability of Rem2 to modulate endogenous voltage-activated calcium channels in rat sympathetic and dorsal root ganglion neurons [1].
 

High impact information on Rem2

  • Individual members of the RGK family of Ras-related GTPases, which comprise Rad, Gem/Kir, Rem and Rem2, have been implicated in important functions such as the regulation of voltage-gated calcium channel activity and remodeling of cell shape [2].
  • Together, our results support a model in which Rem2 localizes to the plasma membrane via a C-terminal polybasic motif and interacts with calcium channel beta subunits in the preassembled N-type channel, thereby forming a nonconducting species [1].

References

  1. Expression of Rem2, an RGK family small GTPase, reduces N-type calcium current without affecting channel surface density. Chen, H., Puhl, H.L., Niu, S.L., Mitchell, D.C., Ikeda, S.R. J. Neurosci. (2005) [Pubmed]
  2. 14-3-3 and calmodulin control subcellular distribution of Kir/Gem and its regulation of cell shape and calcium channel activity. Béguin, P., Mahalakshmi, R.N., Nagashima, K., Cher, D.H., Takahashi, A., Yamada, Y., Seino, Y., Hunziker, W. J. Cell. Sci. (2005) [Pubmed]
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