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Gene Review:

EBF2 - early B-cell factor 2

Homo sapiens

Synonyms: COE2, EBF-2, Early B-cell factor 2, FLJ11500, O/E-3, ...

Jimenez, M.A. et al., Olmedo, G. et al., Trarbach, E.B. et al.

Trarbach, Baptista, Garmes, Hackel,

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High impact information on EBF2

Furthermore, we find that the ethylene insensitivity of ein5 mutant plants is a consequence of the over-accumulation of EBF1 and EBF2 mRNAs resulting in the under-accumulation of EIN3 even in the presence of ethylene gas [1].
Reduction of Ebf1 and Ebf2 proteins by specific short hairpin RNA blocks differentiation of 3T3-L1 cells, suggesting a critical role for these factors and the absence of functional redundancy between members of this family [2].
NELF and EBF2 genes have been considered good candidates for HH and a large number of patients need to be studied to assess their contribution to reproductive function [3].

Biological context of EBF2

Altogether, these data place Ebf1 within the known transcriptional cascade of adipogenesis and suggest critical roles for Ebf1 and Ebf2 [2].

References

Inaugural Article: ETHYLENE-INSENSITIVE5 encodes a 5'->3' exoribonuclease required for regulation of the EIN3-targeting F-box proteins EBF1/2. Olmedo, G., Guo, H., Gregory, B.D., Nourizadeh, S.D., Aguilar-Henonin, L., Li, H., An, F., Guzman, P., Ecker, J.R. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
Critical role for ebf1 and ebf2 in the adipogenic transcriptional cascade. Jimenez, M.A., Akerblad, P., Sigvardsson, M., Rosen, E.D. Mol. Cell. Biol. (2007) [Pubmed]
Molecular analysis of KAL-1, GnRH-R, NELF and EBF2 genes in a series of Kallmann syndrome and normosmic hypogonadotropic hypogonadism patients. Trarbach, E.B., Baptista, M.T., Garmes, H.M., Hackel, C. J. Endocrinol. (2005) [Pubmed]

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