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Gene Review

Ebf2  -  early B cell factor 2

Mus musculus

Synonyms: Coe2, D14Ggc1e, EBF-2, Early B-cell factor 2, MET-mesencephalon-olfactory TF1, ...
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Disease relevance of Ebf2


High impact information on Ebf2

  • The number of Purkinje cells (PCs) in the Ebf2 null is markedly decreased, resulting in a small cerebellum with notable foliation defects, particularly in the anterior vermis [2].
  • In addition to deficits in neuroendocrine and olfactory development, and peripheral nerve maturation, Ebf2 null mice feature an ataxic gait and obvious motor deficits associated with clear-cut abnormalities of cerebellar development [2].
  • Part of the striped cerebellar topography is disrupted due to cell death and, in addition, many of the surviving PCs, that would normally adopt a zebrin II-negative phenotype, transdifferentiate to Zebrin II-positive, an unprecedented finding suggesting that Ebf2 is required for the establishment of a proper cerebellar cortical map [2].
  • In Ebf2-null mutants, because of defective migration of gonadotropin releasing hormone-synthesizing neurons, formation of the neuroendocrine axis (which is essential for pubertal development) is impaired, leading to secondary hypogonadism [1].
  • In addition, Ebf2(-/-) peripheral nerves feature defective axon sorting, hypomyelination, segmental dysmyelination and axonal damage, accompanied by a sharp decrease in motor nerve conduction velocity [1].

Biological context of Ebf2


Anatomical context of Ebf2

  • We find that mice homozygous for a targeted inactivation of Ebf2 show reduced bone mass and an increase in the number of osteoclasts [4].

Associations of Ebf2 with chemical compounds

  • By using gene knockout techniques it has been found that mice carrying a targeted deletion of Ebf2 gene, a component of Olf/Ebf bHLH transcription factors, show a defective migration of GnRH neurons, providing the first evidence of a mouse model of such defect [5].

Other interactions of Ebf2

  • The strong conservation of the protein regions corresponding to the DNA binding and dimerisation domains previously defined in Ebf strongly suggests that Ebf2 and Ebf3 also constitute DNA sequence-specific transcription factors [6].
  • Here, we identify EBF2, a member of the early B cell factor (EBF) family of transcription factors that is expressed in osteoblast progenitors, as a regulator of osteoclast differentiation [4].
  • Taken together, these data identify EBF2 as a regulator of RANK-RANKL signaling and osteoblast-dependent differentiation of osteoclasts [4].

Analytical, diagnostic and therapeutic context of Ebf2


  1. Hypogonadotropic hypogonadism and peripheral neuropathy in Ebf2-null mice. Corradi, A., Croci, L., Broccoli, V., Zecchini, S., Previtali, S., Wurst, W., Amadio, S., Maggi, R., Quattrini, A., Consalez, G.G. Development (2003) [Pubmed]
  2. A key role for the HLH transcription factor EBF2COE2,O/E-3 in Purkinje neuron migration and cerebellar cortical topography. Croci, L., Chung, S.H., Masserdotti, G., Gianola, S., Bizzoca, A., Gennarini, G., Corradi, A., Rossi, F., Hawkes, R., Consalez, G.G. Development (2006) [Pubmed]
  3. Mmot1, a new helix-loop-helix transcription factor gene displaying a sharp expression boundary in the embryonic mouse brain. Malgaretti, N., Pozzoli, O., Bosetti, A., Corradi, A., Ciarmatori, S., Panigada, M., Bianchi, M.E., Martinez, S., Consalez, G.G. J. Biol. Chem. (1997) [Pubmed]
  4. EBF2 regulates osteoblast-dependent differentiation of osteoclasts. Kieslinger, M., Folberth, S., Dobreva, G., Dorn, T., Croci, L., Erben, R., Consalez, G.G., Grosschedl, R. Dev. Cell (2005) [Pubmed]
  5. Factors involved in the migration of neuroendocrine hypothalamic neurons. Maggi, R., Cariboni, A., Zaninetti, R., Samara, A., Stossi, F., Pimpinelli, F., Giacobini, P., Consalez, G.G., Rugarli, E., Piva, F. Archives italiennes de biologie. (2005) [Pubmed]
  6. Family of Ebf/Olf-1-related genes potentially involved in neuronal differentiation and regional specification in the central nervous system. Garel, S., Marín, F., Mattéi, M.G., Vesque, C., Vincent, A., Charnay, P. Dev. Dyn. (1997) [Pubmed]
  7. Molecular cloning of Zcoe2, the zebrafish homolog of Xenopus Xcoe2 and mouse EBF-2, and its expression during primary neurogenesis. Bally-Cuif, L., Dubois, L., Vincent, A. Mech. Dev. (1998) [Pubmed]
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