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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Adipogenesis


Psychiatry related information on Adipogenesis


High impact information on Adipogenesis


Chemical compound and disease context of Adipogenesis


Biological context of Adipogenesis

  • The specificity of the association of lipid globules with vimentin IFs during adipose conversion is discussed as a special form of compartmentalization supporting adipogenesis and is taken as an example of a possible IF function in relation to a cell differentiation process [14].
  • Studies from the past several years have revealed that adipogenesis is controlled by an interplay of transcription factors, including members of the CCAAT/enhancer binding protein family and peroxisome proliferator activated receptor gamma [15].
  • These results define multiple roles for C/EBP alpha in adipogenesis and show that cross-regulation between PPAR gamma and C/EBP alpha is a key component of the transcriptional control of this cell lineage [16].
  • Ecotin, an inhibitor of serine proteases, inhibits cell-shape change, adipocyte-specific gene expression, and lipid accumulation during adipogenesis in culture [17].
  • To examine the long-term function of ADSF in adipogenesis and glucose homeostasis, we constructed an expression vector for a dominant inhibitory form of ADSF by fusing it to the human IgGgamma constant region (hFc) [18].

Anatomical context of Adipogenesis


Associations of Adipogenesis with chemical compounds


Gene context of Adipogenesis


Analytical, diagnostic and therapeutic context of Adipogenesis


  1. Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2. Peng, X.D., Xu, P.Z., Chen, M.L., Hahn-Windgassen, A., Skeen, J., Jacobs, J., Sundararajan, D., Chen, W.S., Crawford, S.E., Coleman, K.G., Hay, N. Genes Dev. (2003) [Pubmed]
  2. The expression of adipogenic genes is decreased in obesity and diabetes mellitus. Nadler, S.T., Stoehr, J.P., Schueler, K.L., Tanimoto, G., Yandell, B.S., Attie, A.D. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  3. Intracellular disposition and metabolic effects of zidovudine, stavudine and four protease inhibitors in cultured adipocytes. Janneh, O., Hoggard, P.G., Tjia, J.F., Jones, S.P., Khoo, S.H., Maher, B., Back, D.J., Pirmohamed, M. Antivir. Ther. (Lond.) (2003) [Pubmed]
  4. Gene expression profiling of orbital adipose tissue from patients with Graves' ophthalmopathy: a potential role for secreted frizzled-related protein-1 in orbital adipogenesis. Kumar, S., Leontovich, A., Coenen, M.J., Bahn, R.S. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  5. Steroid-induced adipogenesis in a pluripotential cell line from bone marrow. Cui, Q., Wang, G.J., Balian, G. The Journal of bone and joint surgery. American volume. (1997) [Pubmed]
  6. Absence of hormone-sensitive lipase inhibits obesity and adipogenesis in Lep ob/ob mice. Sekiya, M., Osuga, J., Okazaki, H., Yahagi, N., Harada, K., Shen, W.J., Tamura, Y., Tomita, S., Iizuka, Y., Ohashi, K., Okazaki, M., Sata, M., Nagai, R., Fujita, T., Shimano, H., Kraemer, F.B., Yamada, N., Ishibashi, S. J. Biol. Chem. (2004) [Pubmed]
  7. A pericellular collagenase directs the 3-dimensional development of white adipose tissue. Chun, T.H., Hotary, K.B., Sabeh, F., Saltiel, A.R., Allen, E.D., Weiss, S.J. Cell (2006) [Pubmed]
  8. Muscle or fat? Rho bridges the GAP. Saltiel, A.R. Cell (2003) [Pubmed]
  9. Modulation of Rho GTPase signaling regulates a switch between adipogenesis and myogenesis. Sordella, R., Jiang, W., Chen, G.C., Curto, M., Settleman, J. Cell (2003) [Pubmed]
  10. E2F repression by C/EBPalpha is required for adipogenesis and granulopoiesis in vivo. Porse, B.T., Pedersen TA, n.u.l.l., Xu, X., Lindberg, B., Wewer, U.M., Friis-Hansen, L., Nerlov, C. Cell (2001) [Pubmed]
  11. 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma. Forman, B.M., Tontonoz, P., Chen, J., Brun, R.P., Spiegelman, B.M., Evans, R.M. Cell (1995) [Pubmed]
  12. The novel hypoglycemic agent YM440 normalizes hyperglycemia without changing body fat weight in diabetic db/db mice. Shimaya, A., Kurosaki, E., Nakano, R., Hirayama, R., Shibasaki, M., Shikama, H. Metab. Clin. Exp. (2000) [Pubmed]
  13. The Nicolas Andry award. The pathogenesis and prevention of steroid-induced osteonecrosis. Wang, G.J., Cui, Q., Balian, G. Clin. Orthop. Relat. Res. (2000) [Pubmed]
  14. Rearrangement of the vimentin cytoskeleton during adipose conversion: formation of an intermediate filament cage around lipid globules. Franke, W.W., Hergt, M., Grund, C. Cell (1987) [Pubmed]
  15. Transcriptional activation of adipogenesis. Wu, Z., Puigserver, P., Spiegelman, B.M. Curr. Opin. Cell Biol. (1999) [Pubmed]
  16. Cross-regulation of C/EBP alpha and PPAR gamma controls the transcriptional pathway of adipogenesis and insulin sensitivity. Wu, Z., Rosen, E.D., Brun, R., Hauser, S., Adelmant, G., Troy, A.E., McKeon, C., Darlington, G.J., Spiegelman, B.M. Mol. Cell (1999) [Pubmed]
  17. A plasma kallikrein-dependent plasminogen cascade required for adipocyte differentiation. Selvarajan, S., Lund, L.R., Takeuchi, T., Craik, C.S., Werb, Z. Nat. Cell Biol. (2001) [Pubmed]
  18. Dominant inhibitory adipocyte-specific secretory factor (ADSF)/resistin enhances adipogenesis and improves insulin sensitivity. Kim, K.H., Zhao, L., Moon, Y., Kang, C., Sul, H.S. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  19. Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. Tontonoz, P., Hu, E., Spiegelman, B.M. Cell (1994) [Pubmed]
  20. Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis. Ge, K., Guermah, M., Yuan, C.X., Ito, M., Wallberg, A.E., Spiegelman, B.M., Roeder, R.G. Nature (2002) [Pubmed]
  21. PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines. Jiang, C., Ting, A.T., Seed, B. Nature (1998) [Pubmed]
  22. PPARgamma knockdown by engineered transcription factors: exogenous PPARgamma2 but not PPARgamma1 reactivates adipogenesis. Ren, D., Collingwood, T.N., Rebar, E.J., Wolffe, A.P., Camp, H.S. Genes Dev. (2002) [Pubmed]
  23. Conditional ectopic expression of C/EBP beta in NIH-3T3 cells induces PPAR gamma and stimulates adipogenesis. Wu, Z., Xie, Y., Bucher, N.L., Farmer, S.R. Genes Dev. (1995) [Pubmed]
  24. Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes. Guan, H.P., Ishizuka, T., Chui, P.C., Lehrke, M., Lazar, M.A. Genes Dev. (2005) [Pubmed]
  25. Inhibition of adipogenesis and development of glucose intolerance by soluble preadipocyte factor-1 (Pref-1). Lee, K., Villena, J.A., Moon, Y.S., Kim, K.H., Lee, S., Kang, C., Sul, H.S. J. Clin. Invest. (2003) [Pubmed]
  26. Biosynthesis of 15-deoxy-delta12,14-PGJ2 and the ligation of PPARgamma. Bell-Parikh, L.C., Ide, T., Lawson, J.A., McNamara, P., Reilly, M., FitzGerald, G.A. J. Clin. Invest. (2003) [Pubmed]
  27. Bone morphogenetic protein and retinoic acid signaling cooperate to induce osteoblast differentiation of preadipocytes. Skillington, J., Choy, L., Derynck, R. J. Cell Biol. (2002) [Pubmed]
  28. Roles of autocrine TGF-beta receptor and Smad signaling in adipocyte differentiation. Choy, L., Skillington, J., Derynck, R. J. Cell Biol. (2000) [Pubmed]
  29. Stromelysin-1 regulates adipogenesis during mammary gland involution. Alexander, C.M., Selvarajan, S., Mudgett, J., Werb, Z. J. Cell Biol. (2001) [Pubmed]
  30. A preadipose 3T3 cell variant highly sensitive to adipogenic factors and to human growth hormone. Salazar-Olivo, L.A., Castro-Muñozledo, F., Kuri-Harcuch, W. J. Cell. Sci. (1995) [Pubmed]
  31. CREB activation induced by mitochondrial dysfunction triggers triglyceride accumulation in 3T3-L1 preadipocytes. Vankoningsloo, S., De Pauw, A., Houbion, A., Tejerina, S., Demazy, C., de Longueville, F., Bertholet, V., Renard, P., Remacle, J., Holvoet, P., Raes, M., Arnould, T. J. Cell. Sci. (2006) [Pubmed]
  32. Basic fibroblast growth factor enhances PPARgamma ligand-induced adipogenesis of mesenchymal stem cells. Neubauer, M., Fischbach, C., Bauer-Kreisel, P., Lieb, E., Hacker, M., Tessmar, J., Schulz, M.B., Goepferich, A., Blunk, T. FEBS Lett. (2004) [Pubmed]
  33. Microarray analysis of early adipogenesis in C3H10T1/2 cells: cooperative inhibitory effects of growth factors and 2,3,7,8-tetrachlorodibenzo-p-dioxin. Hanlon, P.R., Cimafranca, M.A., Liu, X., Cho, Y.C., Jefcoate, C.R. Toxicol. Appl. Pharmacol. (2005) [Pubmed]
  34. Time course of de novo adipogenesis in matrigel by gelatin microspheres incorporating basic fibroblast growth factor. Kimura, Y., Ozeki, M., Inamoto, T., Tabata, Y. Tissue engineering. (2002) [Pubmed]
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