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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

EFCAB6  -  EF-hand calcium binding domain 6

Homo sapiens

Synonyms: CAP-binding protein complex-interacting protein 1, DJ-1-binding protein, DJBP, EF-hand calcium-binding domain-containing protein 6, FLJ23588, ...
 
 
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Disease relevance of FLJ23588

  • Necropsy tissues from 11 cases were analyzed with 1 tumor specimen found to have HIV integrated in chromosome 22q13.2 and within 300 kb of HSCBCIP1 (CAP-binding protein complex interacting homologue) [1].
 

High impact information on FLJ23588

  • These results suggest that AR is positively regulated by DJ-1, which antagonizes the function of negative regulators, including DJBP [2].
  • DJBP mRNA was found to be specifically expressed in the testis [2].
  • In the cases of KIAA1670 and KIAA1672, these single cDNA sequences covered two separately annotated transcribed regions [3].

References

  1. Preferential HIV-1 integration sites in macrophages and HIV-associated malignancies. Killebrew, D.A., Troelstrup, D., Shiramizu, B. Cell. Mol. Biol. (Noisy-le-grand) (2004) [Pubmed]
  2. DJBP: a novel DJ-1-binding protein, negatively regulates the androgen receptor by recruiting histone deacetylase complex, and DJ-1 antagonizes this inhibition by abrogation of this complex. Niki, T., Takahashi-Niki, K., Taira, T., Iguchi-Ariga, S.M., Ariga, H. Mol. Cancer Res. (2003) [Pubmed]
  3. Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping. Hirosawa, M., Nagase, T., Murahashi, Y., Kikuno, R., Ohara, O. DNA Res. (2001) [Pubmed]
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