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Gene Review

Kcnip3  -  Kv channel interacting protein 3, calsenilin

Rattus norvegicus

Synonyms: A-type potassium channel modulatory protein 3, Calsenilin, Csen, DRE-antagonist modulator, DREAM, ...
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High impact information on Csen

  • Zn(2+)-less Kv4.2 channels expressed with KChIP3 demonstrate several distinct kinetic changes in channel gating, including a reduced time to peak and faster entry into the inactivated state as well as extending the time to recover from inactivation by 3-4 fold [1].

Biological context of Csen

  • To test whether CaMKII phosphorylation of Kv4.2 affects channel biophysics, we expressed wild-type or mutant Kv4.2 and the K(+) channel interacting protein, KChIP3, with or without a constitutively active form of CaMKII in Xenopus oocytes and measured the voltage dependence of activation and inactivation in each of these conditions [2].

Other interactions of Csen

  • Multiprotein assembly of Kv4.2, KChIP3 and DPP10 produces ternary channel complexes with ISA-like properties [3].


  1. KChIP3 rescues the functional expression of Shal channel tetramerization mutants. Kunjilwar, K., Strang, C., DeRubeis, D., Pfaffinger, P.J. J. Biol. Chem. (2004) [Pubmed]
  2. Calcium-calmodulin-dependent kinase II modulates Kv4.2 channel expression and upregulates neuronal A-type potassium currents. Varga, A.W., Yuan, L.L., Anderson, A.E., Schrader, L.A., Wu, G.Y., Gatchel, J.R., Johnston, D., Sweatt, J.D. J. Neurosci. (2004) [Pubmed]
  3. Multiprotein assembly of Kv4.2, KChIP3 and DPP10 produces ternary channel complexes with ISA-like properties. Jerng, H.H., Kunjilwar, K., Pfaffinger, P.J. J. Physiol. (Lond.) (2005) [Pubmed]
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