The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

Kcnip3  -  Kv channel interacting protein 3, calsenilin

Rattus norvegicus

Synonyms: A-type potassium channel modulatory protein 3, Calsenilin, Csen, DRE-antagonist modulator, DREAM, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on Csen

  • Zn(2+)-less Kv4.2 channels expressed with KChIP3 demonstrate several distinct kinetic changes in channel gating, including a reduced time to peak and faster entry into the inactivated state as well as extending the time to recover from inactivation by 3-4 fold [1].
 

Biological context of Csen

  • To test whether CaMKII phosphorylation of Kv4.2 affects channel biophysics, we expressed wild-type or mutant Kv4.2 and the K(+) channel interacting protein, KChIP3, with or without a constitutively active form of CaMKII in Xenopus oocytes and measured the voltage dependence of activation and inactivation in each of these conditions [2].
 

Other interactions of Csen

  • Multiprotein assembly of Kv4.2, KChIP3 and DPP10 produces ternary channel complexes with ISA-like properties [3].

References

  1. KChIP3 rescues the functional expression of Shal channel tetramerization mutants. Kunjilwar, K., Strang, C., DeRubeis, D., Pfaffinger, P.J. J. Biol. Chem. (2004) [Pubmed]
  2. Calcium-calmodulin-dependent kinase II modulates Kv4.2 channel expression and upregulates neuronal A-type potassium currents. Varga, A.W., Yuan, L.L., Anderson, A.E., Schrader, L.A., Wu, G.Y., Gatchel, J.R., Johnston, D., Sweatt, J.D. J. Neurosci. (2004) [Pubmed]
  3. Multiprotein assembly of Kv4.2, KChIP3 and DPP10 produces ternary channel complexes with ISA-like properties. Jerng, H.H., Kunjilwar, K., Pfaffinger, P.J. J. Physiol. (Lond.) (2005) [Pubmed]
 
WikiGenes - Universities