Disease relevance of KCNIP3

• Moreover, blocking the calsenilin expression protected the neuronal cells from Abeta toxicity [1].
• Rice nightmare: Kwashiorkor in 2 Philadelphia-area infants fed Rice Dream beverage [2].
• A cure for plantar fasciitis? Dream on [3].
• RESULTS: Three major themes were generated from the data: (a) "Dealing With Death and the Blessings of Life," (b) "Sepsis: The Cancer in the NICU," and (c) "Losing the Dream: Parents' Reactions." The nurses had feelings of helplessness and frustration while caring for these sick newborns [4].

Psychiatry related information on KCNIP3

• In this study, we hypothesized that calsenilin might be involved in the neurodegeneration of Alzheimer's disease and examined calsenilin expression in Alzheimer's disease [1].
• A novel form of group therapy which I call the Dream Seminar was introduced on an inpatient milieu treatment unit for chronic schizophrenic patients at a Veterans Hospital. The purpose was to help patients understand and appreciate their dreams in a special group setting [5].
• It was also hypothesized that by limiting the focus of the Dream Seminar to the manifest dream content, the images and internal sequences of the dream, and by not allowing free association, the connective unconscious of the group would be brought into the open and balance the more conventional therapies of the rest of the program [5].
• It was hypothesized that the Dream Seminar would diminish insomnia and night fears, that the examination of dream experiences, no matter how bizarre or frightening, would be potentially healing, and that patients' attitudes toward dreams as well as delusions and hallucinations might change [5].
• Partial support was found for the hypothesis that Dream Success is related to mental health factors [6].

High impact information on KCNIP3

• Using this PS2 domain in the yeast two-hybrid system, we have identified a neuronal protein that binds calcium and presenilin, which we call calsenilin [7].
• Thus, calsenilin may mediate the effects of wild-type and mutant presenilins on apoptosis and on Abeta formation [7].
• Further characterization of calsenilin may lead to an understanding of the normal role of the presenilins and of the role of the presenilins in Alzheimer disease [7].
• Notably, expression of calsenilin alone had no discernable effects on calcium signaling, suggesting that calsenilin modulates these signals by a mechanism independent of simple calcium buffering [8].
• These results suggest that the vulnerability of CLN3 knock-out or CLN3 deletion (1-153)-expressing neuronal cells to Ca(2+)-induced cell death may be mediated by calsenilin [9].

Chemical compound and disease context of KCNIP3

• To consider the relationships among Type A-B behavior, gender, and specific types of nightmares, 780 university undergraduates were tested with Glass' version of the Jenkins Activity Survey and the Spadafora and Hunt Dream Types Survey which included the critical nightmares (fantastic nightmares, posttraumatic nightmares, and night terrors) [10].

Biological context of KCNIP3

• The expression of calsenilin was highly up-regulated in neuronal cells undergoing Abeta42-triggered cell death [11].
• These findings suggest that chronic up-regulation of calsenilin may be a risk factor for developing Alzheimer's disease, perhaps by facilitating calsenilin-mediated neurodegeneration [1].
• This CA repeat will be useful for linkage and linkage disequilibrium studies to determine whether calsenilin variants contribute to risk in other diseases [12].
• Because calsenilin may play a role in Alzheimer's disease and other disease with alterations in calcium homeostasis, we characterized the human gene [12].
• Down-regulation of CLN3 expression sensitizes SH-SY5Y cells to thapsigargin or A23187 [9].

Anatomical context of KCNIP3

• To establish a direct role for calsenilin in regulating gamma-secretase activity, we incubated purified calsenilin with isolated membrane fractions and found increased Abeta production in a cell free system [13].
• In this study, we investigated the effects of calsenilin on calcium signaling in Xenopus oocytes expressing either wild-type or mutant PS1 [8].
• In stable neuroglioma cell lines, we observed that calsenilin enhances apoptosis in response to serum withdrawal or thapsigargin [14].
• Calsenilin enhances apoptosis by altering endoplasmic reticulum calcium signaling [14].
• The incidence of calsenilin-mediated apoptosis was diminished in presenilin-1(-/-) mouse embryonic fibroblast cells or neuronal cells stably expressing a loss-of-function presenilin-1 mutant [11].

Associations of KCNIP3 with chemical compounds

• A similar effect was observed when cells were treated with pharmacological agents that directly manipulate the levels of intracellular calcium (caffeine and the calcium ionophore A23187), suggesting that the increased levels of calsenilin in the nucleus are mediated by changes in intracellular calcium [15].
• Moreover, gamma-secretase inhibitors, including compound E and DAPT, decreased the calsenilin-induced cell death [11].
• Induction of calsenilin was also observed in the activated astroglia as well as in the neurons surrounding beta-amyloid (Abeta)- and Congo red-positive plaques [1].
• Two of us took 10 capsules or tablets of Dream Shape or Ever Youth, and changes in thyroid hormone levels were observed during the first 24 hours [16].
• Diary of a Dream: The American Society of Regional Anesthesia (for Surgery, Obstetrics, and Pain Control) [17].

Other interactions of KCNIP3

• Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment [7].
• Exposing cultured cortical and hippocampal neurons to Abeta42, an amyloid-beta peptide whose deposition in the brain is a characteristic of Alzheimer's disease, induced both calsenilin protein and mRNA expression, and cell death [1].
• 1. The real-time RT-PCR analysis showed that the relative abundance of the encoding genes of I(A) alpha-subunit and K(V) channel-interacting proteins (KChIPs) was K(V)4.2 > K(V)3.4 > K(V)4.3 (long) > K(V)4.1, and KChIP3 >> KChIP2, respectively [18].
• RESULTS: 22 films, beginning with The Snake Pit and ending with Requiem for a Dream, portraying or making reference to ECT were made between 1948 and 2000 [19].
• Freud, Irma, Martha: sex and marriage in the "Dream of Irma's injection" [20].
• CANT1 seems to have a role in protein quality control. CANT1 has been identified as a novel target of the Calcium-dependent transcriptional repressor DREAM. CANT1 downregulation increased protein degradation. CANT1 overexpression enhances Calcium levels in Golgi apparatus, indicating a role in Calcium homeostasis. Protein degradation represents a novel process modulated by DREAM. [21]

Analytical, diagnostic and therapeutic context of KCNIP3

• Finally, we have demonstrated that calsenilin is a substrate for caspase-3, and we have used site-directed mutagenesis to map the caspase-3 cleavage site to a region that is proximal to the calcium binding domain of calsenilin [22].
• Chemotherapy for advanced bladder cancer: 'Midsummer Night's Dream' or 'Much Ado About Nothing' [23]?
• The Multidimensional Dream Inventory: preliminary evidence for validity and reliability [24].

References