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Gene Review

KCNIP3  -  Kv channel interacting protein 3, calsenilin

Homo sapiens

Synonyms: A-type potassium channel modulatory protein 3, CSEN, Calsenilin, DRE-antagonist modulator, DREAM, ...
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Disease relevance of KCNIP3

  • Moreover, blocking the calsenilin expression protected the neuronal cells from Abeta toxicity [1].
  • Rice nightmare: Kwashiorkor in 2 Philadelphia-area infants fed Rice Dream beverage [2].
  • A cure for plantar fasciitis? Dream on [3].
  • RESULTS: Three major themes were generated from the data: (a) "Dealing With Death and the Blessings of Life," (b) "Sepsis: The Cancer in the NICU," and (c) "Losing the Dream: Parents' Reactions." The nurses had feelings of helplessness and frustration while caring for these sick newborns [4].

Psychiatry related information on KCNIP3

  • In this study, we hypothesized that calsenilin might be involved in the neurodegeneration of Alzheimer's disease and examined calsenilin expression in Alzheimer's disease [1].
  • A novel form of group therapy which I call the Dream Seminar was introduced on an inpatient milieu treatment unit for chronic schizophrenic patients at a Veterans Hospital. The purpose was to help patients understand and appreciate their dreams in a special group setting [5].
  • It was also hypothesized that by limiting the focus of the Dream Seminar to the manifest dream content, the images and internal sequences of the dream, and by not allowing free association, the connective unconscious of the group would be brought into the open and balance the more conventional therapies of the rest of the program [5].
  • It was hypothesized that the Dream Seminar would diminish insomnia and night fears, that the examination of dream experiences, no matter how bizarre or frightening, would be potentially healing, and that patients' attitudes toward dreams as well as delusions and hallucinations might change [5].
  • Partial support was found for the hypothesis that Dream Success is related to mental health factors [6].

High impact information on KCNIP3

  • Using this PS2 domain in the yeast two-hybrid system, we have identified a neuronal protein that binds calcium and presenilin, which we call calsenilin [7].
  • Thus, calsenilin may mediate the effects of wild-type and mutant presenilins on apoptosis and on Abeta formation [7].
  • Further characterization of calsenilin may lead to an understanding of the normal role of the presenilins and of the role of the presenilins in Alzheimer disease [7].
  • Notably, expression of calsenilin alone had no discernable effects on calcium signaling, suggesting that calsenilin modulates these signals by a mechanism independent of simple calcium buffering [8].
  • These results suggest that the vulnerability of CLN3 knock-out or CLN3 deletion (1-153)-expressing neuronal cells to Ca(2+)-induced cell death may be mediated by calsenilin [9].

Chemical compound and disease context of KCNIP3

  • To consider the relationships among Type A-B behavior, gender, and specific types of nightmares, 780 university undergraduates were tested with Glass' version of the Jenkins Activity Survey and the Spadafora and Hunt Dream Types Survey which included the critical nightmares (fantastic nightmares, posttraumatic nightmares, and night terrors) [10].

Biological context of KCNIP3


Anatomical context of KCNIP3


Associations of KCNIP3 with chemical compounds


Other interactions of KCNIP3

  • Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment [7].
  • Exposing cultured cortical and hippocampal neurons to Abeta42, an amyloid-beta peptide whose deposition in the brain is a characteristic of Alzheimer's disease, induced both calsenilin protein and mRNA expression, and cell death [1].
  • 1. The real-time RT-PCR analysis showed that the relative abundance of the encoding genes of I(A) alpha-subunit and K(V) channel-interacting proteins (KChIPs) was K(V)4.2 > K(V)3.4 > K(V)4.3 (long) > K(V)4.1, and KChIP3 >> KChIP2, respectively [18].
  • RESULTS: 22 films, beginning with The Snake Pit and ending with Requiem for a Dream, portraying or making reference to ECT were made between 1948 and 2000 [19].
  • Freud, Irma, Martha: sex and marriage in the "Dream of Irma's injection" [20].
  • CANT1 seems to have a role in protein quality control. CANT1 has been identified as a novel target of the Calcium-dependent transcriptional repressor DREAM. CANT1 downregulation increased protein degradation. CANT1 overexpression enhances Calcium levels in Golgi apparatus, indicating a role in Calcium homeostasis. Protein degradation represents a novel process modulated by DREAM. [21]

Analytical, diagnostic and therapeutic context of KCNIP3


  1. Induction of pro-apoptotic calsenilin/DREAM/KChIP3 in Alzheimer's disease and cultured neurons after amyloid-beta exposure. Jo, D.G., Lee, J.Y., Hong, Y.M., Song, S., Mook-Jung, I., Koh, J.Y., Jung, Y.K. J. Neurochem. (2004) [Pubmed]
  2. Rice nightmare: Kwashiorkor in 2 Philadelphia-area infants fed Rice Dream beverage. Katz, K.A., Mahlberg, M.H., Honig, P.J., Yan, A.C. J. Am. Acad. Dermatol. (2005) [Pubmed]
  3. A cure for plantar fasciitis? Dream on. Haslam, D. The Practitioner (2006) [Pubmed]
  4. The lived experience of nurses caring for newborns with sepsis. Rubarth, L.B. Journal of obstetric, gynecologic, and neonatal nursing : JOGNN / NAACOG. (2003) [Pubmed]
  5. Dream seminar for chronic schizophrenic patients. Wilmer, H.A. Psychiatry. (1982) [Pubmed]
  6. The dream in midlife women: its impact on mental health. Drebing, C.E., Gooden, W.E., Drebing, S.M., Van de Kemp, H., Malony, H.N. International journal of aging & human development. (1995) [Pubmed]
  7. Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment. Buxbaum, J.D., Choi, E.K., Luo, Y., Lilliehook, C., Crowley, A.C., Merriam, D.E., Wasco, W. Nat. Med. (1998) [Pubmed]
  8. Calsenilin reverses presenilin-mediated enhancement of calcium signaling. Leissring, M.A., Yamasaki, T.R., Wasco, W., Buxbaum, J.D., Parker, I., LaFerla, F.M. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  9. Neuronal vulnerability of CLN3 deletion to calcium-induced cytotoxicity is mediated by calsenilin. Chang, J.W., Choi, H., Kim, H.J., Jo, D.G., Jeon, Y.J., Noh, J.Y., Park, W.J., Jung, Y.K. Hum. Mol. Genet. (2007) [Pubmed]
  10. Type A-B behavior and nightmare types among college students. Tan, V.L., Hicks, R.A. Perceptual and motor skills. (1995) [Pubmed]
  11. Contribution of presenilin/gamma-secretase to calsenilin-mediated apoptosis. Jo, D.G., Chang, J.W., Hong, H.S., Mook-Jung, I., Jung, Y.K. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  12. Genomic structure, expression pattern, and chromosomal localization of the human calsenilin gene: no association between an exonic polymorphism and Alzheimer's disease. Buxbaum, J.D., Lilliehook, C., Chan, J.Y., Go, R.C., Bassett, S.S., Tanzi, R.E., Wasco, W., Blacker, D. Neurosci. Lett. (2000) [Pubmed]
  13. Overexpression of calsenilin enhances gamma-secretase activity. Jo, D.G., Jang, J., Kim, B.J., Lundkvist, J., Jung, Y.K. Neurosci. Lett. (2005) [Pubmed]
  14. Calsenilin enhances apoptosis by altering endoplasmic reticulum calcium signaling. Lilliehook, C., Chan, S., Choi, E.K., Zaidi, N.F., Wasco, W., Mattson, M.P., Buxbaum, J.D. Mol. Cell. Neurosci. (2002) [Pubmed]
  15. Intracellular calcium modulates the nuclear translocation of calsenilin. Zaidi, N.F., Thomson, E.E., Choi, E.K., Buxbaum, J.D., Wasco, W. J. Neurochem. (2004) [Pubmed]
  16. Thyrotoxicosis caused by weight-reducing herbal medicines. Ohye, H., Fukata, S., Kanoh, M., Kubota, S., Kuma, K., Miyauchi, A., Sugawara, M. Arch. Intern. Med. (2005) [Pubmed]
  17. Diary of a Dream: The American Society of Regional Anesthesia (for Surgery, Obstetrics, and Pain Control). Winnie, A.P. Regional anesthesia and pain medicine (2006) [Pubmed]
  18. Molecular and pharmacological characteristics of transient voltage-dependent K+ currents in cultured human pulmonary arterial smooth muscle cells. Iida, H., Jo, T., Iwasawa, K., Morita, T., Hikiji, H., Takato, T., Toyo-Oka, T., Nagai, R., Nakajima, T. Br. J. Pharmacol. (2005) [Pubmed]
  19. The portrayal of ECT in American movies. McDonald, A., Walter, G. The journal of ECT. (2001) [Pubmed]
  20. Freud, Irma, Martha: sex and marriage in the "Dream of Irma's injection". Elms, A.C. Psychoanalytic review. (1980) [Pubmed]
  21. Ca2+-activated nucleotidase 1, a novel target gene for the transcriptional repressor DREAM (Downstream Regulatory Element Antagonist Modulator), is involved in protein folding and degradation. Cali, T., Fedrizzi, L., Ottolini, D., Gomez-Villafuertes, R., Mellstrom, B., Naranjo, J.R., Carafoli, E., Brini, M. J. Biol. Chem. (2012) [Pubmed]
  22. Calsenilin is a substrate for caspase-3 that preferentially interacts with the familial Alzheimer's disease-associated C-terminal fragment of presenilin 2. Choi, E.K., Zaidi, N.F., Miller, J.S., Crowley, A.C., Merriam, D.E., Lilliehook, C., Buxbaum, J.D., Wasco, W. J. Biol. Chem. (2001) [Pubmed]
  23. Chemotherapy for advanced bladder cancer: 'Midsummer Night's Dream' or 'Much Ado About Nothing'? Raghavan, D. Br. J. Cancer (1990) [Pubmed]
  24. The Multidimensional Dream Inventory: preliminary evidence for validity and reliability. Kallmeyer, R.J., Chang, E.C. Perceptual and motor skills. (1997) [Pubmed]
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