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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SRP68  -  signal recognition particle 68kDa

Homo sapiens

Synonyms: Signal recognition particle 68 kDa protein, Signal recognition particle subunit SRP68
 
 
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Disease relevance of SRP68

  • The depletion of SRP72 and SRP68 induced sudden death, most probably as a result of toxicity due to the accumulation of the pre-SRP in the nucleolus [1].
  • Human SRP68 was purified from overexpressing Escherichia coli cells and was found to bind to recombinant SRP72 as well as in vitro-transcribed human SRP RNA [2].
 

High impact information on SRP68

  • In transfected rat fibroblasts, green fluorescent protein fusions of SRP19, SRP68, and SRP72 localized to the nucleolus, as well as to the cytoplasm, as expected [3].
  • SRP68 also accumulated in the ER, consistent with its affinity for the ER-bound SRP receptor [3].
 

Biological context of SRP68

 

Physical interactions of SRP68

  • Ninety-four amino acids near the C terminus of SRP68 mediated the binding to SRP72 [2].

References

  1. The Trypanosoma brucei signal recognition particle lacks the Alu-domain-binding proteins: purification and functional analysis of its binding proteins by RNAi. Lustig, Y., Goldshmidt, H., Uliel, S., Michaeli, S. J. Cell. Sci. (2005) [Pubmed]
  2. Protein SRP68 of human signal recognition particle: identification of the RNA and SRP72 binding domains. Iakhiaeva, E., Bhuiyan, S.H., Yin, J., Zwieb, C. Protein Sci. (2006) [Pubmed]
  3. Signal recognition particle components in the nucleolus. Politz, J.C., Yarovoi, S., Kilroy, S.M., Gowda, K., Zwieb, C., Pederson, T. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
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