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MeSH Review

Death, Sudden

 
 
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Disease relevance of Death, Sudden

 

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Chemical compound and disease context of Death, Sudden

 

Biological context of Death, Sudden

 

Anatomical context of Death, Sudden

 

Gene context of Death, Sudden

  • Mutations of the gene (TNNT2) encoding the thin-filament contractile protein cardiac troponin T are responsible for 15% of all cases of familial hypertrophic cardiomyopathy, the leading cause of sudden death in young athletes [31].
  • We have screened SCN5A in a large 8-generation kindred characterized by a high incidence of nocturnal sudden death, and QT-interval prolongation and the "Brugada ECG" occurring in the same subjects [32].
  • Our findings indicate for the first time that substantially decreased heart HSP90 is associated with HCM pigs with sudden death [33].
  • CONCLUSIONS: In this autopsy series, only 2 of 12 patients with unexplained sudden death were observed to have a defect in HERG among five candidate genes tested [34].
  • The HCM patients with MYH7 mutations more often had a family history of HCM (43% vs. 29%, p = 0.006), but there was no difference in family history of sudden death (16% vs. 14%, p = NS) [35].
 

Analytical, diagnostic and therapeutic context of Death, Sudden

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