The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Death, Sudden

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Death, Sudden


Psychiatry related information on Death, Sudden


High impact information on Death, Sudden


Chemical compound and disease context of Death, Sudden


Biological context of Death, Sudden


Anatomical context of Death, Sudden


Gene context of Death, Sudden

  • Mutations of the gene (TNNT2) encoding the thin-filament contractile protein cardiac troponin T are responsible for 15% of all cases of familial hypertrophic cardiomyopathy, the leading cause of sudden death in young athletes [31].
  • We have screened SCN5A in a large 8-generation kindred characterized by a high incidence of nocturnal sudden death, and QT-interval prolongation and the "Brugada ECG" occurring in the same subjects [32].
  • Our findings indicate for the first time that substantially decreased heart HSP90 is associated with HCM pigs with sudden death [33].
  • CONCLUSIONS: In this autopsy series, only 2 of 12 patients with unexplained sudden death were observed to have a defect in HERG among five candidate genes tested [34].
  • The HCM patients with MYH7 mutations more often had a family history of HCM (43% vs. 29%, p = 0.006), but there was no difference in family history of sudden death (16% vs. 14%, p = NS) [35].

Analytical, diagnostic and therapeutic context of Death, Sudden


  1. Evidence of apoptosis in arrhythmogenic right ventricular dysplasia. Mallat, Z., Tedgui, A., Fontaliran, F., Frank, R., Durigon, M., Fontaine, G. N. Engl. J. Med. (1996) [Pubmed]
  2. Nifedipine in unstable angina: a double-blind, randomized trial. Gerstenblith, G., Ouyang, P., Achuff, S.C., Bulkley, B.H., Becker, L.C., Mellits, E.D., Baughman, K.L., Weiss, J.L., Flaherty, J.T., Kallman, C.H., Llewellyn, M., Weisfeldt, M.L. N. Engl. J. Med. (1982) [Pubmed]
  3. Sustained arrhythmias in hypertrophic obstructive cardiomyopathy. Kowey, P.R., Eisenberg, R., Engel, T.R. N. Engl. J. Med. (1984) [Pubmed]
  4. SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome. Wang, Q., Shen, J., Splawski, I., Atkinson, D., Li, Z., Robinson, J.L., Moss, A.J., Towbin, J.A., Keating, M.T. Cell (1995) [Pubmed]
  5. A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome. Curran, M.E., Splawski, I., Timothy, K.W., Vincent, G.M., Green, E.D., Keating, M.T. Cell (1995) [Pubmed]
  6. Bupropion and the risk of sudden death: a self-controlled case-series analysis using The Health Improvement Network. Hubbard, R., Lewis, S., West, J., Smith, C., Godfrey, C., Smeeth, L., Farrington, P., Britton, J. Thorax (2005) [Pubmed]
  7. Association of paraoxonase-1 M55L genotype and alcohol consumption with coronary atherosclerosis: the Helsinki Sudden Death Study. Rontu, R., Lehtimäki, T., Ilveskoski, E., Mikkelsson, J., Kajander, O., Goebeler, S., Perola, M., Penttilä, A., Karhunen, P.J. Pharmacogenetics (2004) [Pubmed]
  8. Cardiovascular safety of sildenafil. Tran, D., Howes, L.G. Drug safety : an international journal of medical toxicology and drug experience. (2003) [Pubmed]
  9. A perspective on neuropathologic findings in victims of the sudden infant death syndrome: the triple-risk model. Filiano, J.J., Kinney, H.C. Biol. Neonate (1994) [Pubmed]
  10. Bisoprolol for the treatment of chronic heart failure: a meta-analysis on individual data of two placebo-controlled studies--CIBIS and CIBIS II. Cardiac Insufficiency Bisoprolol Study. Leizorovicz, A., Lechat, P., Cucherat, M., Bugnard, F. Am. Heart J. (2002) [Pubmed]
  11. Lamr1 functional retroposon causes right ventricular dysplasia in mice. Asano, Y., Takashima, S., Asakura, M., Shintani, Y., Liao, Y., Minamino, T., Asanuma, H., Sanada, S., Kim, J., Ogai, A., Fukushima, T., Oikawa, Y., Okazaki, Y., Kaneda, Y., Sato, M., Miyazaki, J., Kitamura, S., Tomoike, H., Kitakaze, M., Hori, M. Nat. Genet. (2004) [Pubmed]
  12. Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias. Wang, Q., Curran, M.E., Splawski, I., Burn, T.C., Millholland, J.M., VanRaay, T.J., Shen, J., Timothy, K.W., Vincent, G.M., de Jager, T., Schwartz, P.J., Toubin, J.A., Moss, A.J., Atkinson, D.L., Landes, G.M., Connors, T.D., Keating, M.T. Nat. Genet. (1996) [Pubmed]
  13. Amiodarone in patients with congestive heart failure and asymptomatic ventricular arrhythmia. Survival Trial of Antiarrhythmic Therapy in Congestive Heart Failure. Singh, S.N., Fletcher, R.D., Fisher, S.G., Singh, B.N., Lewis, H.D., Deedwania, P.C., Massie, B.M., Colling, C., Lazzeri, D. N. Engl. J. Med. (1995) [Pubmed]
  14. Coronary-artery vasoconstriction induced by cocaine, cigarette smoking, or both. Moliterno, D.J., Willard, J.E., Lange, R.A., Negus, B.H., Boehrer, J.D., Glamann, D.B., Landau, C., Rossen, J.D., Winniford, M.D., Hillis, L.D. N. Engl. J. Med. (1994) [Pubmed]
  15. Sudden death in young athletes. Lessons from the Hank Gathers affair. Maron, B.J. N. Engl. J. Med. (1993) [Pubmed]
  16. Intravenous propylhexedrine and sudden death. White, L., DiMaio, V.J. N. Engl. J. Med. (1977) [Pubmed]
  17. Sudden death in infants sleeping on polystyrene-filled cushions. Kemp, J.S., Thach, B.T. N. Engl. J. Med. (1991) [Pubmed]
  18. Fish consumption and risk of sudden cardiac death. Albert, C.M., Hennekens, C.H., O'Donnell, C.J., Ajani, U.A., Carey, V.J., Willett, W.C., Ruskin, J.N., Manson, J.E. JAMA (1998) [Pubmed]
  19. Infantile form of carnitine palmitoyltransferase II deficiency with hepatomuscular symptoms and sudden death. Physiopathological approach to carnitine palmitoyltransferase II deficiencies. Demaugre, F., Bonnefont, J.P., Colonna, M., Cepanec, C., Leroux, J.P., Saudubray, J.M. J. Clin. Invest. (1991) [Pubmed]
  20. Prolonged QT interval and risk of sudden death in South-East Asian men. Munger, R.G., Prineas, R.J., Crow, R.S., Changbumrung, S., Keane, V., Wangsuphachart, V., Jones, M.P. Lancet (1991) [Pubmed]
  21. Should survivors of myocardial infarction with low ejection fraction be routinely referred to arrhythmia specialists? Stevenson, W.G., Ridker, P.M. JAMA (1996) [Pubmed]
  22. Electrophysiological abnormalities and arrhythmias in alpha MHC mutant familial hypertrophic cardiomyopathy mice. Berul, C.I., Christe, M.E., Aronovitz, M.J., Seidman, C.E., Seidman, J.G., Mendelsohn, M.E. J. Clin. Invest. (1997) [Pubmed]
  23. Expression of protein kinase C beta in the heart causes hypertrophy in adult mice and sudden death in neonates. Bowman, J.C., Steinberg, S.F., Jiang, T., Geenen, D.L., Fishman, G.I., Buttrick, P.M. J. Clin. Invest. (1997) [Pubmed]
  24. The role of platelets in acute vascular events. Harker, L.A., Ritchie, J.L. Circulation (1980) [Pubmed]
  25. Gating currents associated with intramembrane charge displacement in HERG potassium channels. Piper, D.R., Varghese, A., Sanguinetti, M.C., Tristani-Firouzi, M. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  26. Screening for hypertrophic cardiomyopathy in young athletes. Corrado, D., Basso, C., Schiavon, M., Thiene, G. N. Engl. J. Med. (1998) [Pubmed]
  27. Mitochondrial deficiency and cardiac sudden death in mice lacking the MEF2A transcription factor. Naya, F.J., Black, B.L., Wu, H., Bassel-Duby, R., Richardson, J.A., Hill, J.A., Olson, E.N. Nat. Med. (2002) [Pubmed]
  28. Variables predictive of successful medical therapy in patients with unstable angina: selection by multivariate analysis from clinical, electrocardiographic, and angiographic evaluations. Ouyang, P., Brinker, J.A., Mellits, E.D., Weisfeldt, M.L., Gerstenblith, G. Circulation (1984) [Pubmed]
  29. Morning sympathetic nerve activity is not increased in humans. Implications for mechanisms underlying the circadian pattern of cardiac risk. Middlekauff, H.R., Sontz, E.M. Circulation (1995) [Pubmed]
  30. Increase in atherosclerosis and adventitial mast cells in cocaine abusers: an alternative mechanism of cocaine-associated coronary vasospasm and thrombosis. Kolodgie, F.D., Virmani, R., Cornhill, J.F., Herderick, E.E., Smialek, J. J. Am. Coll. Cardiol. (1991) [Pubmed]
  31. Cardiac troponin T is essential in sarcomere assembly and cardiac contractility. Sehnert, A.J., Huq, A., Weinstein, B.M., Walker, C., Fishman, M., Stainier, D.Y. Nat. Genet. (2002) [Pubmed]
  32. A single Na(+) channel mutation causing both long-QT and Brugada syndromes. Bezzina, C., Veldkamp, M.W., van Den Berg, M.P., Postma, A.V., Rook, M.B., Viersma, J.W., van Langen, I.M., Tan-Sindhunata, G., Bink-Boelkens, M.T., van Der Hout, A.H., Mannens, M.M., Wilde, A.A. Circ. Res. (1999) [Pubmed]
  33. Substantial decrease of heat shock protein 90 in ventricular tissues of two sudden-death pigs with hypertrophic cardiomyopathy. Lee, W.C., Lin, K.Y., Chiu, Y.T., Lin, J.H., Cheng, H.C., Huang, H.C., Yang, P.C., Liu, S.K., Mao, S.J. FASEB J. (1996) [Pubmed]
  34. Postmortem molecular screening in unexplained sudden death. Chugh, S.S., Senashova, O., Watts, A., Tran, P.T., Zhou, Z., Gong, Q., Titus, J.L., Hayflick, S.J. J. Am. Coll. Cardiol. (2004) [Pubmed]
  35. Comprehensive analysis of the beta-myosin heavy chain gene in 389 unrelated patients with hypertrophic cardiomyopathy. Van Driest, S.L., Jaeger, M.A., Ommen, S.R., Will, M.L., Gersh, B.J., Tajik, A.J., Ackerman, M.J. J. Am. Coll. Cardiol. (2004) [Pubmed]
  36. Efficacy of implantable cardioverter-defibrillators for the prevention of sudden death in patients with hypertrophic cardiomyopathy. Maron, B.J., Shen, W.K., Link, M.S., Epstein, A.E., Almquist, A.K., Daubert, J.P., Bardy, G.H., Favale, S., Rea, R.F., Boriani, G., Estes, N.A., Spirito, P. N. Engl. J. Med. (2000) [Pubmed]
  37. Sudden death caused by interaction between a macroglobulin and a divalent drug. Harboe, M., Folling, I. Lancet (1976) [Pubmed]
  38. Prognosis of asymptomatic patients with hypertrophic cardiomyopathy and nonsustained ventricular tachycardia. Spirito, P., Rapezzi, C., Autore, C., Bruzzi, P., Bellone, P., Ortolani, P., Fragola, P.V., Chiarella, F., Zoni-Berisso, M., Branzi, A. Circulation (1994) [Pubmed]
  39. Comparison of d,l-sotalol and implantable defibrillators for treatment of sustained ventricular tachycardia or fibrillation in patients with coronary artery disease. Böcker, D., Haverkamp, W., Block, M., Borggrefe, M., Hammel, D., Breithardt, G. Circulation (1996) [Pubmed]
  40. Sudden death in cancer patients receiving lithium. Lyman, G.H., Williams, C.C., Dinwoodie, W.R., Schocken, D.D. J. Clin. Oncol. (1984) [Pubmed]
WikiGenes - Universities