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Gene Review:

STAC - SH3 and cysteine rich domain

Homo sapiens

Synonyms: SH3 and cysteine-rich domain-containing protein, STAC1, Src homology 3 and cysteine-rich domain-containing protein

De Vleeschauwer, A. et al., Kemény, V. et al., Kawai, J. et al., Petek, E. et al.

Petek, Emberger, Kroisel, Wagner, Kemény, Droste, Hermes, Nabavi, Schulte-Altedorneburg, Siebler, Ringelstein,

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Disease relevance of STAC

The purpose of this study was to evaluate the critical conditions of automated embolus detection by means of a trained neural network (EMBotec V5.1 One, STAC GmbH, Germany) [1].

High impact information on STAC

By radiation hybrid mapping, STAC was assigned to human chromosome 3p22-p24, and it was found to be distinct from the ADCA type II locus [2].
The HemosIL von Willebrand Factor Activity assay, a new automated immunological test to measure VWF activity, was implemented on STAC and compared with the von Willebrand ristocetin cofactor activity (VWF:RCo) aggregation method [3].

Biological context of STAC

Assignment of STAC to human chromosome band 3p22.3 between D3S3718 and D3S1611 [4].

References

Automatic embolus detection by a neural network. Kemény, V., Droste, D.W., Hermes, S., Nabavi, D.G., Schulte-Altedorneburg, G., Siebler, M., Ringelstein, E.B. Stroke (1999) [Pubmed]
Human and mouse chromosomal mapping of Stac, a neuron-specific protein with an SH3 domain. Kawai, J., Suzuki, H., Hara, A., Hirose, K., Watanabe, S. Genomics (1998) [Pubmed]
Comparison of a new automated von Willebrand factor activity assay with an aggregation von Willebrand ristocetin cofactor activity assay for the diagnosis of von Willebrand disease. De Vleeschauwer, A., Devreese, K. Blood Coagul. Fibrinolysis (2006) [Pubmed]
Assignment of STAC to human chromosome band 3p22.3 between D3S3718 and D3S1611. Petek, E., Emberger, W., Kroisel, P.M., Wagner, K. Cytogenet. Cell Genet. (1999) [Pubmed]

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STAC	Bos taurus
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stac	Danio rerio
STAC	Gallus gallus
STAC	Macaca mulatta
Stac	Mus musculus
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stac	Xenopus (Silurana) tropicalis

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