The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Embolism


High impact information on Embolism

  • Therefore, we investigated whether warfarin, which is effective and superior to aspirin in the prevention of cardiogenic embolism, would also prove superior in the prevention of recurrent ischemic stroke in patients with a prior noncardioembolic ischemic stroke [6].
  • Images in clinical medicine. Bullet embolism [7].
  • For some patients, it was possible to reduce dopamine agonists used immediately after the drug holiday without causing deterioration, but a pulmonary embolus and other complications occurred [8].
  • In addition, we found that Gas6 antibodies inhibited platelet aggregation in vitro and protected mice against fatal thrombo embolism without causing bleeding in vivo [1].
  • Thrombolysis by human tissue plasminogen activator and urokinase in rabbits with experimental pulmonary embolus [9].

Chemical compound and disease context of Embolism


Biological context of Embolism


Anatomical context of Embolism


Gene context of Embolism

  • On univariate analysis, DFS was significantly decreased in a context of low GSTP1 expression (P = 0.0005) and high SBR grade (P = 0.003), size > or = 5 cm (P = 0.038), high T stage (P = 0.013), presence of intravascular embolus (P = 0.034), and >3 N+ (P = 0.05) [25].
  • 3-[2-[4-(3-Chloro-2-methylphenylmethyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole Dihydro-chloride 3.5 Hydrate (DY-9760e) Is Neuroprotective in Rat Microsphere Embolism: Role of the Cross-Talk between Calpain and Caspase-3 through Calpastatin [26].
  • Moreover, MUC5AC appears related to lesser embolism [27].
  • MMP-1, -7 and -13 were not correlated with either emboli number or with maximum embolus size [28].
  • Higher expression of uPA mRNA and PAI-1 mRNA were detected in tumor tissues and embolus [29].

Analytical, diagnostic and therapeutic context of Embolism


  1. Deficiency or inhibition of Gas6 causes platelet dysfunction and protects mice against thrombosis. Angelillo-Scherrer, A., de Frutos, P., Aparicio, C., Melis, E., Savi, P., Lupu, F., Arnout, J., Dewerchin, M., Hoylaerts, M., Herbert, J., Collen, D., Dahlbäck, B., Carmeliet, P. Nat. Med. (2001) [Pubmed]
  2. Indobufen in the prevention of thromboembolic complications in patients with heart disease. A randomized, placebo-controlled, double-blind study. Fornaro, G., Rossi, P., Mantica, P.G., Caccia, M.E., Aralda, D., Lavezzari, M., Pamparana, F., Milanesi, G. Circulation (1993) [Pubmed]
  3. Platelet suppressant therapy in patients with prosthetic cardiac valves. Relationship of clinical effectiveness to alteration of platelet survival time. Steele, P., Rainwater, J., Vogel, R. Circulation (1979) [Pubmed]
  4. Aortoventriculoplasty in infants and children. Frommelt, P.C., Lupinetti, F.M., Bove, E.L. Circulation (1992) [Pubmed]
  5. Increased expression and activity of matrix metalloproteinases characterize embolic cardiac myxomas. Orlandi, A., Ciucci, A., Ferlosio, A., Pellegrino, A., Chiariello, L., Spagnoli, L.G. Am. J. Pathol. (2005) [Pubmed]
  6. A comparison of warfarin and aspirin for the prevention of recurrent ischemic stroke. Mohr, J.P., Thompson, J.L., Lazar, R.M., Levin, B., Sacco, R.L., Furie, K.L., Kistler, J.P., Albers, G.W., Pettigrew, L.C., Adams, H.P., Jackson, C.M., Pullicino, P. N. Engl. J. Med. (2001) [Pubmed]
  7. Images in clinical medicine. Bullet embolism. Rajamani, K., Fisher, M. N. Engl. J. Med. (1998) [Pubmed]
  8. Reappraisal of temporary levodopa withdrawal ("drug holiday") in Parkinson's disease. Mayeux, R., Stern, Y., Mulvey, K., Cote, L. N. Engl. J. Med. (1985) [Pubmed]
  9. Thrombolysis by human tissue plasminogen activator and urokinase in rabbits with experimental pulmonary embolus. Matsuo, O., Rijken, D.C., Collen, D. Nature (1981) [Pubmed]
  10. Deep venous thrombosis and pulmonary embolism. Frequency in a respiratory intensive care unit. Moser, K.M., LeMoine, J.R., Nachtwey, F.J., Spragg, R.G. JAMA (1981) [Pubmed]
  11. Massive pulmonary embolus and anabolic steroid abuse. Gaede, J.T., Montine, T.J. JAMA (1992) [Pubmed]
  12. Vaginal prostaglandin E2 and fatal amniotic fluid embolus. Less, A., Goldberger, S.B., Bernheim, J., Ben-Nun, I., Fejgin, M.D. JAMA (1990) [Pubmed]
  13. Thromboxane mediation of cardiopulmonary effects of embolism. Utsonomiya, T., Krausz, M.M., Levine, L., Shepro, D., Hechtman, H.B. J. Clin. Invest. (1982) [Pubmed]
  14. Cholesterol crystal embolism. Marinella, M.A. Lancet (1996) [Pubmed]
  15. Relationship of sialyl-Lewis(x/a) underexpression and E-cadherin overexpression in the lymphovascular embolus of inflammatory breast carcinoma. Alpaugh, M.L., Tomlinson, J.S., Ye, Y., Barsky, S.H. Am. J. Pathol. (2002) [Pubmed]
  16. Early anticoagulation after large cerebral embolic infarction: a safety study. Chamorro, A., Vila, N., Saiz, A., Alday, M., Tolosa, E. Neurology (1995) [Pubmed]
  17. Changes in striatal dopamine metabolism after microsphere embolism in rats. Takagi, N., Tsuru, H., Yamamura, M., Takeo, S. Stroke (1995) [Pubmed]
  18. Unmasking of thrombin vasoconstriction in isolated perfused dog hearts after intracoronary infusion of air embolus. Ku, D.D. J. Pharmacol. Exp. Ther. (1987) [Pubmed]
  19. Impairment of cerebral cAMP-mediated signal transduction system and of spatial memory function after microsphere embolism in rats. Nagakura, A., Takagi, N., Takeo, S. Neuroscience (2002) [Pubmed]
  20. A comparison of aspirin with placebo in patients treated with warfarin after heart-valve replacement. Turpie, A.G., Gent, M., Laupacis, A., Latour, Y., Gunstensen, J., Basile, F., Klimek, M., Hirsh, J. N. Engl. J. Med. (1993) [Pubmed]
  21. Vascular outcome in men with asymptomatic retinal cholesterol emboli. A cohort study. Bruno, A., Jones, W.L., Austin, J.K., Carter, S., Qualls, C. Ann. Intern. Med. (1995) [Pubmed]
  22. Serum concentration of intercellular adhesion molecule-1 in patients with hepatocellular carcinoma is a marker of the disease progression and prognosis. Shimizu, Y., Minemura, M., Tsukishiro, T., Kashii, Y., Miyamoto, M., Nishimori, H., Higuchi, K., Watanabe, A. Hepatology (1995) [Pubmed]
  23. Cooperative role of E-cadherin and sialyl-Lewis X/A-deficient MUC1 in the passive dissemination of tumor emboli in inflammatory breast carcinoma. Alpaugh, M.L., Tomlinson, J.S., Kasraeian, S., Barsky, S.H. Oncogene (2002) [Pubmed]
  24. Ischemic renal diseases: new insights into old entities. Meyrier, A., Hill, G.S., Simon, P. Kidney Int. (1998) [Pubmed]
  25. Prognostic impact of multidrug resistance gene expression on the management of breast cancer in the context of adjuvant therapy based on a series of 171 patients. Moureau-Zabotto, L., Ricci, S., Lefranc, J.P., Coulet, F., Genestie, C., Antoine, M., Uzan, S., Lotz, J.P., Touboul, E., Lacave, R. Br. J. Cancer (2006) [Pubmed]
  26. 3-[2-[4-(3-Chloro-2-methylphenylmethyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole Dihydro-chloride 3.5 Hydrate (DY-9760e) Is Neuroprotective in Rat Microsphere Embolism: Role of the Cross-Talk between Calpain and Caspase-3 through Calpastatin. Han, F., Shirasaki, Y., Fukunaga, K. J. Pharmacol. Exp. Ther. (2006) [Pubmed]
  27. MUC1, MUC2 and MUC5AC expressions in cardiac myxoma. Chu, P.H., Jung, S.M., Yeh, T.S., Lin, H.C., Chu, J.J. Virchows Arch. (2005) [Pubmed]
  28. The relationship between plasma MMP-1, -7, -8 and -13 levels and embolic potential during carotid endoluminal intervention. Bicknell, C.D., Peck, D., Lau, N.M., Alkhamesi, N.A., Cowling, M.G., Clark, M.W., Jenkins, M.P., Wolfe, J.H., Darzi, A.W., Cheshire, N.J. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery. (2004) [Pubmed]
  29. Invasion and metastasis of hepatocellular carcinoma in relation to urokinase-type plasminogen activator, its receptor and inhibitor. Zheng, Q., Tang, Z.Y., Xue, Q., Shi, D.R., Song, H.Y., Tang, H.B. J. Cancer Res. Clin. Oncol. (2000) [Pubmed]
  30. Probability of metabolic tissue recovery after thrombolytic treatment of experimental stroke: a magnetic resonance spectroscopic imaging study in rat brain. Franke, C., Brinker, G., Pillekamp, F., Hoehn, M. J. Cereb. Blood Flow Metab. (2000) [Pubmed]
  31. Infarcts with a cardiac source of embolism in the NINDS Stroke Data Bank: neurologic examination. Kittner, S.J., Sharkness, C.M., Sloan, M.A., Price, T.R., Dambrosia, J.M., Tuhrim, S., Wolf, P.A., Mohr, J.P., Hier, D.B., Caplan, L.R. Neurology (1992) [Pubmed]
  32. Possible pulmonary embolus: evaluation with digital subtraction versus cut-film angiography--prospective study in 80 patients. Johnson, M.S., Stine, S.B., Shah, H., Harris, V.J., Ambrosius, W.T., Trerotola, S.O. Radiology. (1998) [Pubmed]
  33. Comprehensive ventilation/perfusion SPECT. Palmer, J., Bitzén, U., Jonson, B., Bajc, M. J. Nucl. Med. (2001) [Pubmed]
WikiGenes - Universities