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Gene Review

SUPV3L1  -  suppressor of var1, 3-like 1 (S. cerevisiae)

Homo sapiens

Synonyms: ATP-dependent RNA helicase SUPV3L1, mitochondrial, SUV3, SUV3-like protein 1, Suppressor of var1 3-like protein 1
 
 
 

High impact information on SUPV3L1

  • Assignment1 of SUPV3L1 to human chromosome band 10q22.1 by in situ hybridization [1].
  • Northern blot data and analysis of ESTs in the data banks indicate that this human gene (SUPV3L1) is expressed in practically all tissues, though at different levels [2].
  • SUPV3L1 protein (SUV3p, hSUV3p, SUV3) is an RNA/DNA helicase and is necessary for proper RNA degradation in human mitochondria, it regulates the stability of mature mtRNAs and is responsible for the degradation of processing intermediates transcribed both from L- and H-strands [3].
  • SUPV3L1 protein forms a complex with PNPase (polynucleotide phosphorylase) which is an RNA-degrading enzyme.
  • SUPV3L1 protein is localized mainly in mitochondrial matrix, but several non-mitochondrial interactors were reported: HBXIP, BLM helicase (Pereira et al., 2007), replication protein A (RPA) and flap endonuclease FEN1 (Veno et al., 2011).
  • Downregulation of SUPV3L1 in HeLa cells induces apoptosis (Szczesny et al., 2007), disruption in mouse results in skin damage, sarcopenia, loss of fat and death (Paul et al., 2009).
  • X-ray crystallographic structure of human SUV3p has been described [4].

 

References

  1. Assignment1 of SUPV3L1 to human chromosome band 10q22.1 by in situ hybridization. Dmochowska, A., Stankiewicz, P., Golik, P., Stepien, P.P., Bocian, E., Hansmann, I., Bartnik, E. Cytogenet. Cell Genet. (1998) [Pubmed]
  2. A human putative Suv3-like RNA helicase is conserved between Rhodobacter and all eukaryotes. Dmochowska, A., Kalita, K., Krawczyk, M., Golik, P., Mroczek, K., Lazowska, J., Stepień, P.P., Bartnik, E. Acta Biochim. Pol. (1999) [Pubmed]
  3. Human mitochondrial RNA turnover caught in flagranti: involvement of hSuv3p helicase in RNA surveillance. Szczesny, R.J., Borowski, L.S., Brzezniak, L.K., Dmochowska, A., Gewartowski, K., Bartnik, E., Stepien, P.P. Nucleic. Acids. Res. (2010) [Pubmed]
  4. Human Suv3 protein reveals unique features among SF2 helicases. Jedrzejczak, R., Wang, J., Dauter, M., Szczesny, R.J., Stepien, P.P., Dauter, Z. Acta. Crystallogr. D. Biol. Crystallogr. (2011) [Pubmed]
 
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