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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Northern blot data and analysis of ESTs in the data banks indicate that this human gene (SUPV3L1) is expressed in practically all tissues, though at different levels [4].
SUPV3L1 protein (SUV3p, hSUV3p, SUV3) is an RNA/DNA helicase and is necessary for proper RNA degradation in human mitochondria, it regulates the stability of mature mtRNAs and is responsible for the degradation of processing intermediates transcribed both from L- and H-strands (Szczesny at al, 2010)
SUPV3L1 protein forms a complex with PNPase (polynucleotide phosphorylase) which is an RNA-degrading enzyme
SUPV3L1 protein is localized mainly in mitochondrial matrix, but several non-mitochondrial interactors were reported: HBXIP (Ref), BLM helicase (Pereira et al., 2007), replication protein A (RPA) and flap endonuclease FEN1 (Veno et al., 2011)
Downregulation of SUPV3L1 in HeLa cells induces apoptosis (Szczesny et al., 2007), disruption in mouse results in skin damage, sarcopenia, loss of fat and death (Paul et al., 2009)
X-ray crystallographic structure of human SUV3p has been described (Jedrzejczak et al., 2011)
