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Gene Review

TAF12  -  TAF12 RNA polymerase II, TATA box binding...

Homo sapiens

Synonyms: TAF15, TAF2J, TAFII-20/TAFII-15, TAFII20, TAFII20/TAFII15, ...
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High impact information on TAF12

  • Remarkably, HFD-mediated interaction enhanced the DNA binding activity of each of the TAF6-TAF9 and TAF4b-TAF12 pairs and of a histone-like octamer complex composed of the four TAFs [1].
  • This indicates that either full-length TAF4 contains an unusually long connecting loop between its second and third helix, and this helix is not required for stable interaction with TAF12, or that TAF4 represents a novel class of partial histone fold motifs [2].
  • In support of this conclusion, chromatin immunoprecipitation experiments confirm the interaction of ATF7 with TAF12 on an ATF7-responsive promoter, in the absence of any artificial overexpression of both proteins [3].
  • We also show that the TAF12-dependent transcriptional activation is competitively inhibited by TAF4 [3].
  • This protein is able to heterodimerize with Jun or Fos proteins and its transcriptional activity is mediated by interaction with TAF12, a subunit of the general transcription factor TFIID [4].

Other interactions of TAF12

  • Although both TAF12 isoforms (TAF12-1 and -2, formerly TAF(II)20 and TAF(II)15) interact with the ATF7 activation region through their histone-fold domain, only the largest, hsTAF12-1, mediates transcriptional activation through its N-terminal region [3].
  • Furthermore, SUMO conjugation inhibits ATF7 transactivation activity by (i) impairing its association with TAF12 and (ii) blocking its binding-to-specific sequences within target promoters [4].


  1. Core promoter binding by histone-like TAF complexes. Shao, H., Revach, M., Moshonov, S., Tzuman, Y., Gazit, K., Albeck, S., Unger, T., Dikstein, R. Mol. Cell. Biol. (2005) [Pubmed]
  2. Crystal structure of a subcomplex of human transcription factor TFIID formed by TATA binding protein-associated factors hTAF4 (hTAF(II)135) and hTAF12 (hTAF(II)20). Werten, S., Mitschler, A., Romier, C., Gangloff, Y.G., Thuault, S., Davidson, I., Moras, D. J. Biol. Chem. (2002) [Pubmed]
  3. A functional interaction between ATF7 and TAF12 that is modulated by TAF4. Hamard, P.J., Dalbies-Tran, R., Hauss, C., Davidson, I., Kedinger, C., Chatton, B. Oncogene (2005) [Pubmed]
  4. Sumoylation delays the ATF7 transcription factor subcellular localization and inhibits its transcriptional activity. Hamard, P.J., Boyer-Guittaut, M., Camuzeaux, B., Dujardin, D., Hauss, C., Oelgeschläger, T., Vigneron, M., Kedinger, C., Chatton, B. Nucleic Acids Res. (2007) [Pubmed]
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