The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

TAF6  -  TAF6 RNA polymerase II, TATA box binding...

Homo sapiens

Synonyms: MGC:8964, RNA polymerase II TBP-associated factor subunit E, TAF(II)70, TAF(II)80, TAF2E, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of TAF6


High impact information on TAF6

  • Furthermore, HFD-mediated interaction stimulated sequence-specific binding by TAF6 and TAF9 [2].
  • We also observed that N-CoR directly interacts with each of the basal factors, TFIIB and TAFII70, and can simultaneously interact with all three basal factors in a non-competitive manner [3].
  • Expression of TAFII70 RNA and protein during oogenesis and development of the amphibian Pleurodeles waltl [4].
  • TAFII70 protein, which is present in fertilized eggs and throughout development, progressively shows a lower level of expression starting from the neurula stage [4].
  • In this paper, we demonstrate that E2 proteins associate in vitro with several TAFs, in particular with TAFII250 and TAFII80 [5].

Biological context of TAF6

  • Both isoforms induce expression of the G2 arrest associated gene, GADD45a, but a novel protein-protein interaction was observed between TAFII70 (not TAFII80) and GADD45a, suggesting that this interaction is important for the observed growth arrest phenotype induced by the TAFII70 isoform [6].
  • TAFII70 protein can play a role in lampbrush transcription; alternatively TAFII70 can be considered a component in the subset of TFIID complexes that do not function during oogenesis, but are accumulated in the oocyte for later use during early development [7].
  • In spreads of GV content, anti-hTAFII70 monoclonal antibody (mAb) stained Cajal bodies (CBs) that were either attached to specific sites on the lampbrush chromosomes or free in the nucleoplasm [7].

Anatomical context of TAF6

  • The predominant forms found in normal and neoplastic breast epithelial cells are shown to be 72 kDa (TAFII70) and 78 kDa (TAFII80) [6].
  • GADD45a null cells are not subject to TAFII70 inhibition, further supporting the relevance of this interaction [6].
  • The localization of the TATA-binding protein (TBP) associated factor II70 (TAFII70) in the germinal vesicle (GV) of newt oocytes was investigated [7].

Analytical, diagnostic and therapeutic context of TAF6


  1. The downstream activation sequence of the strict late Herpes Simplex Virus Type 1 U(L)38 promoter interacts with hTAF(II)70, a component of TFIID. Petroski, M.D., Devi-Rao, G.B., Rice, M.K., Wagner, E.K. Virus Genes (2001) [Pubmed]
  2. Core promoter binding by histone-like TAF complexes. Shao, H., Revach, M., Moshonov, S., Tzuman, Y., Gazit, K., Albeck, S., Unger, T., Dikstein, R. Mol. Cell. Biol. (2005) [Pubmed]
  3. The corepressor N-CoR and its variants RIP13a and RIP13Delta1 directly interact with the basal transcription factors TFIIB, TAFII32 and TAFII70. Muscat, G.E., Burke, L.J., Downes, M. Nucleic Acids Res. (1998) [Pubmed]
  4. Expression of TAFII70 RNA and protein during oogenesis and development of the amphibian Pleurodeles waltl. Giani, L., Bucci, S., Ragghianti, M., Mancino, G. Mech. Dev. (2000) [Pubmed]
  5. Specific in vitro interaction between papillomavirus E2 proteins and TBP-associated factors. Carrillo, E., Garrido, E., Gariglio, P. Intervirology (2004) [Pubmed]
  6. TAFII70 isoform-specific growth suppression correlates with its ability to complex with the GADD45a protein. Wang, W., Nahta, R., Huper, G., Marks, J.R. Mol. Cancer Res. (2004) [Pubmed]
  7. TAFII70 protein in Cajal bodies of the amphibian germinal vesicle. Bucci, S., Giani, L., Mancino, G., Pellegrino, M., Ragghianti, M. Genome (2001) [Pubmed]
  8. Cloning and expression of Drosophila TAFII60 and human TAFII70 reveal conserved interactions with other subunits of TFIID. Weinzierl, R.O., Ruppert, S., Dynlacht, B.D., Tanese, N., Tjian, R. EMBO J. (1993) [Pubmed]
WikiGenes - Universities