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Gene Review

TAF4  -  TAF4 RNA polymerase II, TATA box binding...

Homo sapiens

Synonyms: RNA polymerase II TBP-associated factor subunit C, TAF(II)130, TAF(II)135, TAF2C, TAF2C1, ...
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Disease relevance of TAF4


Psychiatry related information on TAF4


High impact information on TAF4


Biological context of TAF4


Anatomical context of TAF4


Associations of TAF4 with chemical compounds


Regulatory relationships of TAF4

  • These results suggest a dynamic TFIID structure in which the switch from a basal hTAF(II)-enhanced repression state to an activator-mediated activated state on a promoter may be mediated in part through activator or coactivator interactions with hTAF(II)135 [12].

Other interactions of TAF4

  • To elucidate the structural organization and function of TFIID, we expressed and characterized the product of a cloned cDNA encoding human TAF(II)135 (hTAF(II)135) [12].
  • Comparative far Western blots have shown that hTAF(II)135 interacts strongly with hTAF(II)20, moderately with hTAF(II)150, and weakly with hTAF(II)43 and hTAF(II)250 [12].
  • This indicates that either full-length TAF4 contains an unusually long connecting loop between its second and third helix, and this helix is not required for stable interaction with TAF12, or that TAF4 represents a novel class of partial histone fold motifs [13].
  • Molecular cloning and analysis of two subunits of the human TFIID complex: hTAFII130 and hTAFII100 [14].
  • The central domain of hTAFII130 contains four glutamine-rich regions, designated Q1 to Q4, that are involved in interactions with the transcriptional activator Sp1 [15].


  1. The transactivation domain of adenovirus E1A interacts with the C terminus of human TAF(II)135. Mazzarelli, J.M., Mengus, G., Davidson, I., Ricciardi, R.P. J. Virol. (1997) [Pubmed]
  2. The human TFIID components TAF(II)135 and TAF(II)20 and the yeast SAGA components ADA1 and TAF(II)68 heterodimerize to form histone-like pairs. Gangloff, Y.G., Werten, S., Romier, C., Carré, L., Poch, O., Moras, D., Davidson, I. Mol. Cell. Biol. (2000) [Pubmed]
  3. Coordinate regulation of RARgamma2, TBP, and TAFII135 by targeted proteolysis during retinoic acid-induced differentiation of F9 embryonal carcinoma cells. Perletti, L., Kopf, E., Carré, L., Davidson, I. BMC Mol. Biol. (2001) [Pubmed]
  4. The RITE assay: identifying effectors that target the transcription machinery using phage display technology. Mazzarelli, J.M., Ricciardi, R.P. BioTechniques (2001) [Pubmed]
  5. Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease. Dunah, A.W., Jeong, H., Griffin, A., Kim, Y.M., Standaert, D.G., Hersch, S.M., Mouradian, M.M., Young, A.B., Tanese, N., Krainc, D. Science (2002) [Pubmed]
  6. Expanded polyglutamine stretches interact with TAFII130, interfering with CREB-dependent transcription. Shimohata, T., Nakajima, T., Yamada, M., Uchida, C., Onodera, O., Naruse, S., Kimura, T., Koide, R., Nozaki, K., Sano, Y., Ishiguro, H., Sakoe, K., Ooshima, T., Sato, A., Ikeuchi, T., Oyake, M., Sato, T., Aoyagi, Y., Hozumi, I., Nagatsu, T., Takiyama, Y., Nishizawa, M., Goto, J., Kanazawa, I., Davidson, I., Tanese, N., Takahashi, H., Tsuji, S. Nat. Genet. (2000) [Pubmed]
  7. Human TAFII 105 is a cell type-specific TFIID subunit related to hTAFII130. Dikstein, R., Zhou, S., Tjian, R. Cell (1996) [Pubmed]
  8. Human TAF(II)135 potentiates transcriptional activation by the AF-2s of the retinoic acid, vitamin D3, and thyroid hormone receptors in mammalian cells. Mengus, G., May, M., Carré, L., Chambon, P., Davidson, I. Genes Dev. (1997) [Pubmed]
  9. A functional interaction between ATF7 and TAF12 that is modulated by TAF4. Hamard, P.J., Dalbies-Tran, R., Hauss, C., Davidson, I., Kedinger, C., Chatton, B. Oncogene (2005) [Pubmed]
  10. Chromatin-dependent cooperativity between constitutive and inducible activation domains in CREB. Asahara, H., Santoso, B., Guzman, E., Du, K., Cole, P.A., Davidson, I., Montminy, M. Mol. Cell. Biol. (2001) [Pubmed]
  11. The activation domain of the enhancer binding protein p45NF-E2 interacts with TAFII130 and mediates long-range activation of the alpha- and beta-globin gene loci in an erythroid cell line. Amrolia, P.J., Ramamurthy, L., Saluja, D., Tanese, N., Jane, S.M., Cunningham, J.M. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  12. Positive and negative TAF(II) functions that suggest a dynamic TFIID structure and elicit synergy with traps in activator-induced transcription. Guermah, M., Tao, Y., Roeder, R.G. Mol. Cell. Biol. (2001) [Pubmed]
  13. Crystal structure of a subcomplex of human transcription factor TFIID formed by TATA binding protein-associated factors hTAF4 (hTAF(II)135) and hTAF12 (hTAF(II)20). Werten, S., Mitschler, A., Romier, C., Gangloff, Y.G., Thuault, S., Davidson, I., Moras, D. J. Biol. Chem. (2002) [Pubmed]
  14. Molecular cloning and analysis of two subunits of the human TFIID complex: hTAFII130 and hTAFII100. Tanese, N., Saluja, D., Vassallo, M.F., Chen, J.L., Admon, A. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  15. Distinct subdomains of human TAFII130 are required for interactions with glutamine-rich transcriptional activators. Saluja, D., Vassallo, M.F., Tanese, N. Mol. Cell. Biol. (1998) [Pubmed]
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