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Gene Review

TAF13  -  TAF13 RNA polymerase II, TATA box binding...

Homo sapiens

Synonyms: TAF(II)18, TAF2K, TAFII-18, TAFII18, Transcription initiation factor TFIID 18 kDa subunit, ...
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High impact information on TAF13

  • The histone folds in hTAF(II)28 and hTAF(II)18 were not predicted from their primary sequence, indicating that these TAF(II)s define a novel family of atypical histone fold sequences [1].
  • Determination of the crystal structure of the human TBP-associated factor (hTAF(II))28/hTAF(II)18 heterodimer shows that these TAF(II)s form a novel histone-like pair in the TFIID complex [1].
  • A sixth essential gene (FUN81) has previously been noted to be similar to human TAFII18 [2].
  • Amino acid sequence comparisons between human SPT3 (hSPT3) and its counterparts in different yeast species reveal three highly conserved domains, with the most conserved 92-amino acid N-terminal domain being 25% identical with human TAFII18 [3].


  1. Human TAF(II)28 and TAF(II)18 interact through a histone fold encoded by atypical evolutionary conserved motifs also found in the SPT3 family. Birck, C., Poch, O., Romier, C., Ruff, M., Mengus, G., Lavigne, A.C., Davidson, I., Moras, D. Cell (1998) [Pubmed]
  2. Yeast homologues of higher eukaryotic TFIID subunits. Moqtaderi, Z., Yale, J.D., Struhl, K., Buratowski, S. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  3. A human SPT3-TAFII31-GCN5-L acetylase complex distinct from transcription factor IID. Martinez, E., Kundu, T.K., Fu, J., Roeder, R.G. J. Biol. Chem. (1998) [Pubmed]
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