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Gene Review

SUPT3H  -  suppressor of Ty 3 homolog (S. cerevisiae)

Homo sapiens

Synonyms: SPT3, SPT3-like protein, SPT3L, Transcription initiation protein SPT3 homolog
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High impact information on SUPT3H

  • The defect in HO expression caused by a mutant SWI/SNF with a Swi2(E834K) substitution can be partially suppressed by ash1 or spt3 mutation or by a gain-of-function V71E substitution in the TATA-binding protein (TBP) [1].
  • Amino acid sequence comparisons between human SPT3 (hSPT3) and its counterparts in different yeast species reveal three highly conserved domains, with the most conserved 92-amino acid N-terminal domain being 25% identical with human TAFII18 [2].
  • Spt3 is a Saccharomyces cerevisiae transcription factor that is required in vivo for the transcription of a number of RNA polymerase II-transcribed genes [3].
  • The two gene structures are therefore "interlocked". In the human genome, SUPT3H is instead interlocked with RUNX2 [4].

Analytical, diagnostic and therapeutic context of SUPT3H


  1. SWI/SNF binding to the HO promoter requires histone acetylation and stimulates TATA-binding protein recruitment. Mitra, D., Parnell, E.J., Landon, J.W., Yu, Y., Stillman, D.J. Mol. Cell. Biol. (2006) [Pubmed]
  2. A human SPT3-TAFII31-GCN5-L acetylase complex distinct from transcription factor IID. Martinez, E., Kundu, T.K., Fu, J., Roeder, R.G. J. Biol. Chem. (1998) [Pubmed]
  3. Characterization of a human homologue of the Saccharomyces cerevisiae transcription factor spt3 (SUPT3H). Yu, J., Madison, J.M., Mundlos, S., Winston, F., Olsen, B.R. Genomics (1998) [Pubmed]
  4. An enigmatic fourth runt domain gene in the fugu genome: ancestral gene loss versus accelerated evolution. Glusman, G., Kaur, A., Hood, L., Rowen, L. BMC Evol. Biol. (2004) [Pubmed]
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