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Gene Review

Oxsm  -  3-oxoacyl-ACP synthase, mitochondrial

Mus musculus

Synonyms: 4933425A18Rik, Beta-ketoacyl-ACP synthase, C80494
 
 
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High impact information on Oxsm

  • The substrate specificity and complementation data for the beta-ketoacyl synthase suggest that, as in plants and fungi, in humans this pathway may play an important role in the generation of octanoyl-acyl carrier protein, the lipoic acid precursor, as well as longer chain fatty acids that are required for optimal mitochondrial function [1].
  • This conclusion was supported by the identification of highly conserved Pks domains for a beta-ketoacyl synthase, an acetyl-malonyl transferase, two acyl carrier proteins, and a thioesterase in the deduced amino acid sequence [2].

References

  1. Cloning, expression, and characterization of the human mitochondrial beta-ketoacyl synthase. Complementation of the yeast CEM1 knock-out strain. Zhang, L., Joshi, A.K., Hofmann, J., Schweizer, E., Smith, S. J. Biol. Chem. (2005) [Pubmed]
  2. Molecular cloning and characterization of WdPKS1, a gene involved in dihydroxynaphthalene melanin biosynthesis and virulence in Wangiella (Exophiala) dermatitidis. Feng, B., Wang, X., Hauser, M., Kaufmann, S., Jentsch, S., Haase, G., Becker, J.M., Szaniszlo, P.J. Infect. Immun. (2001) [Pubmed]
 
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