Gene Review:
OXSM - 3-oxoacyl-ACP synthase, mitochondrial
Homo sapiens
Synonyms:
Beta-ketoacyl-ACP synthase, FASN2D, FLJ20604, KASI, KS
- Cloning and expression of the multifunctional human fatty acid synthase and its subdomains in Escherichia coli. Jayakumar, A., Huang, W.Y., Raetz, B., Chirala, S.S., Wakil, S.J. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Kinetics of Kaposi's sarcoma-associated herpesvirus gene expression. Sun, R., Lin, S.F., Staskus, K., Gradoville, L., Grogan, E., Haase, A., Miller, G. J. Virol. (1999)
- Discovery of a new source of rifamycin antibiotics in marine sponge actinobacteria by phylogenetic prediction. Kim, T.K., Hewavitharana, A.K., Shaw, P.N., Fuerst, J.A. Appl. Environ. Microbiol. (2006)
- Cerebellar volume decline in normal aging, alcoholism, and Korsakoff's syndrome: relation to ataxia. Sullivan, E.V., Deshmukh, A., Desmond, J.E., Lim, K.O., Pfefferbaum, A. Neuropsychology. (2000)
- Evolutionary diversity of ketoacyl synthases in cellulolytic myxobacterium Sorangium. Li, Z.F., Zhao, J.Y., Xia, Z.J., Shi, J., Liu, H., Wu, Z.H., Hu, W., Liu, W.F., Li, Y.Z. Syst. Appl. Microbiol. (2007)
- The 2.7-Angstrom crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase. Tang, Y., Kim, C.Y., Mathews, I.I., Cane, D.E., Khosla, C. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Synthesis and antitumor activity of an inhibitor of fatty acid synthase. Kuhajda, F.P., Pizer, E.S., Li, J.N., Mani, N.S., Frehywot, G.L., Townsend, C.A. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Human fatty acid synthase: properties and molecular cloning. Jayakumar, A., Tai, M.H., Huang, W.Y., al-Feel, W., Hsu, M., Abu-Elheiga, L., Chirala, S.S., Wakil, S.J. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Evolutionary implications of bacterial polyketide synthases. Jenke-Kodama, H., Sandmann, A., Müller, R., Dittmann, E. Mol. Biol. Evol. (2005)
- Triclosan inhibits enoyl-reductase of type I fatty acid synthase in vitro and is cytotoxic to MCF-7 and SKBr-3 breast cancer cells. Liu, B., Wang, Y., Fillgrove, K.L., Anderson, V.E. Cancer Chemother. Pharmacol. (2002)
- Diterpene synthesis in Stevia rebaudiana: recruitment and up-regulation of key enzymes from the gibberellin biosynthetic pathway. Richman, A.S., Gijzen, M., Starratt, A.N., Yang, Z., Brandle, J.E. Plant J. (1999)
- Origin of starter units for erythromycin biosynthesis. Weissman, K.J., Bycroft, M., Staunton, J., Leadlay, P.F. Biochemistry (1998)
- Type I polyketide synthases may have evolved through horizontal gene transfer. Ginolhac, A., Jarrin, C., Robe, P., Perrière, G., Vogel, T.M., Simonet, P., Nalin, R. J. Mol. Evol. (2005)
- Mechanism of the beta-ketoacyl synthase reaction catalyzed by the animal fatty acid synthase. Witkowski, A., Joshi, A.K., Smith, S. Biochemistry (2002)
- Kaposi's sarcoma: clinico-pathological analysis of human immunodeficiency virus (HIV) and non-HIV associated cases. Hong, A., Lee, C.S. Pathol. Oncol. Res. (2002)
- Application of an enzyme-linked immunosorbent-inhibition assay to quantitate the release of KS peptides into fluids of the rat subcutaneous air-pouch model and the effects of chondroprotective drugs on the release process. Kongtawelert, P., Francis, D.J., Brooks, P.M., Ghosh, P. Rheumatol. Int. (1989)
- Functional analysis of the two interacting cyclase domains in ent-kaurene synthase from the fungus Phaeosphaeria sp. L487 and a comparison with cyclases from higher plants. Kawaide, H., Sassa, T., Kamiya, Y. J. Biol. Chem. (2000)
- Conversion of a beta-ketoacyl synthase to a malonyl decarboxylase by replacement of the active-site cysteine with glutamine. Witkowski, A., Joshi, A.K., Lindqvist, Y., Smith, S. Biochemistry (1999)
- Biochemical analysis of the substrate specificity of the beta-ketoacyl-acyl carrier protein synthase domain of module 2 of the erythromycin polyketide synthase. Wu, J., Kinoshita, K., Khosla, C., Cane, D.E. Biochemistry (2004)
- An unusual beta-ketoacyl:acyl carrier protein synthase and acyltransferase motifs in TaK, a putative protein required for biosynthesis of the antibiotic TA in Myxococcus xanthus. Paitan, Y., Orr, E., Ron, E.Z., Rosenberg, E. FEMS Microbiol. Lett. (2001)
- A spontaneous albino mutant of Ceratocystis resinifera results from a point mutation in the polyketide synthase gene, PKS1. Tanguay, P., Loppnau, P., Morin, C., Bernier, L., Breuil, C. Can. J. Microbiol. (2006)
- CE-LIF coupled with flow cytometry for high-throughput quantitation of fluorophores in single intact cells. Xiao, H., Li, X., Zou, H., Yang, L., Wang, Y., Wang, H., Le, X.C. Electrophoresis (2006)
- The polyketide synthase gene pks4 from Gibberella fujikuroi encodes a key enzyme in the biosynthesis of the red pigment bikaverin. Linnemannstöns, P., Schulte, J., del Mar Prado, M., Proctor, R.H., Avalos, J., Tudzynski, B. Fungal Genet. Biol. (2002)
- Gibberellin biosynthesis in Gibberella fujikuroi: cloning and characterization of the copalyl diphosphate synthase gene. Tudzynski, B., Kawaide, H., Kamiya, Y. Curr. Genet. (1998)