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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

C1QC  -  complement component 1, q subcomponent, C...

Homo sapiens

Synonyms: C1Q-C, C1QG, Complement C1q subcomponent subunit C
 
 
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High impact information on C1QC

  • The sequence identity of the nucleotide sequence with human C1q C chain is 79%, the identity of the deduced amino acid sequences is 73% [1].
  • RESULTS: The C-chain of complement C1q (C1q-C) was detected to interact with FKBP13 in the yeast two-hybrid system and in a protein complementation assay [2].
  • In three instances mRNA was detected in the absence of secreted protein: mRNAs for the C1qA and C1qC chains were detected in HUVEC, whereas the mRNA for the C1qB chain was not, and C4 mRNA was detected in both fibroblasts and HUVEC.(ABSTRACT TRUNCATED AT 250 WORDS)[3]
  • C1q was only synthesised by monocytes, although the mRNAs for the C1qA and C1qC chains were expressed in HUVEC [4].
 

Other interactions of C1QC

  • Binding of C1q-C to FKBP13 could not be prevented in the presence of FK506, demonstrating that possibly other regions than the binding pocket of the drug are responsible for the interaction of the two proteins [2].
 

Analytical, diagnostic and therapeutic context of C1QC

  • Southern blot analysis of chromosomal DNA from 14 vertebrate species demonstrated highest similarity between the C1qB genes, followed by C1qC and finally C1qA [5].

References

  1. Isolation, sequence analysis and characterization of cDNA clones coding for the C chain of mouse C1q. Sequence similarity of complement subcomponent C1q, collagen type VIII and type X and precerebellin. Petry, F., Reid, K.B., Loos, M. Eur. J. Biochem. (1992) [Pubmed]
  2. The FK506 binding protein 13 kDa (FKBP13) interacts with the C-chain of complement C1q. Neye, H., Verspohl, E.J. BMC Pharmacol. (2004) [Pubmed]
  3. Expression of the components and regulatory proteins of the classical pathway of complement in normal and diseased synovium. Gulati, P., Guc, D., Lemercier, C., Lappin, D., Whaley, K. Rheumatol. Int. (1994) [Pubmed]
  4. Regulation of the synthesis of C1 subcomponents and C1-inhibitor. Gulati, P., Lemercier, C., Guc, D., Lappin, D., Whaley, K. Behring Inst. Mitt. (1993) [Pubmed]
  5. The mouse C1q genes are clustered on chromosome 4 and show conservation of gene organization. Petry, F., McClive, P.J., Botto, M., Morley, B.J., Morahan, G., Loos, M. Immunogenetics (1996) [Pubmed]
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