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Gene Review:

TRR-TCT2-1 - transfer RNA-Arg (TCT) 2-1

Homo sapiens

Synonyms: TRNAR1, TRR1

Tsuchiya, H. et al., Kern, A.J. et al., Missall, T.A. et al.

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Disease relevance of TRNAR1

Three independent Tax1-responsive regions (TRRs) were identified, and mutations in each revealed that one of the retinoblastoma control elements in TRR1 and the c-fos AP-1 sites in TRR2 and TRR3 were essential for the activation [1].

High impact information on TRNAR1

In the F(2) populations, assortment of S and R phenotypes fit a 15:1 segregation ratio, suggesting that resistance was controlled by the two independently segregating recessive genes TRR1 and TRR2 [2].
Thioredoxin reductase (TRR1) is an important component of the thioredoxin oxidative stress resistance pathway [3].

References

Human T-cell leukemia virus type 1 Tax activates transcription of the human fra-1 gene through multiple cis elements responsive to transmembrane signals. Tsuchiya, H., Fujii, M., Niki, T., Tokuhara, M., Matsui, M., Seiki, M. J. Virol. (1993) [Pubmed]
Two recessive gene inheritance for triallate resistance in Avena fatua L. Kern, A.J., Myers, T.M., Jasieniuk, M., Murray, B.G., Maxwell, B.D., Dyer, W.E. J. Hered. (2002) [Pubmed]
Thioredoxin reductase is essential for viability in the fungal pathogen Cryptococcus neoformans. Missall, T.A., Lodge, J.K. Eukaryotic Cell (2005) [Pubmed]

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