The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Genes, Recessive

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Genes, Recessive


High impact information on Genes, Recessive


Chemical compound and disease context of Genes, Recessive


Biological context of Genes, Recessive


Anatomical context of Genes, Recessive


Associations of Genes, Recessive with chemical compounds

  • Genetic analysis suggests that melatonin deficiency in C57BL/6J mice results from mutations in two independently segregating, autosomal recessive genes [21].
  • Specifically, selective adult type lactose malabsorptions seem to be inherited by a single autosomal recessive gene [22].
  • The observed frequencies of HYPERREACTIVE and HYPOREACTIVE phenotypes in the (A/J x C3H/HeJ) F1; (C3H/HeJ x A/J) F1 x C3H/HeJ (C3H/HeJ backcross); and the [(A/J x C3H/HeJ) F1 x (C3H/HeJ x A/J) F1] F2 are consistent with a single autosomal recessive gene primarily controlling acetylcholine-mediated airway responses [23].
  • The resistance to fenpropimorph involves two recessive genes, each of which allows a semiresistance, when they are isolated apart from one another [24].
  • Black eyes of the moth of Heliothis virescens were controlled by a single, autosomal recessive gene, b [25].

Gene context of Genes, Recessive

  • The recessive gene for HFE is unknown but closely linked to the HLA-A locus [26].
  • In contrast, defective TCR induced IL-4 production (which appeared to be a unique property of SJL mice) seems to be controlled by two recessive genes unlinked to NKR-P1 [27].
  • The family study results were compatible with the model that the low activity type is due to an autosomal recessive gene, which indicates that DNASE2 L represents homozygosity for DNASE2*L and DNASE2 H corresponds to homozygosity for DNASE2*H and heterozygosity for DNASE2*L and DNASE2*H [28].
  • Linkage analyses showed that DT-APR was controlled by two recessive genes, ltnr1 and ltnr2, which were mapped on chromosome 3 and 11, respectively [29].
  • TNNI3 is the first recessive gene identified for this condition, and we suggest that other such genes could be pinpointed by mutation analyses designed to identify homozygous mutations [30].

Analytical, diagnostic and therapeutic context of Genes, Recessive


  1. Accelerated rate of mononuclear phagocyte production in vitro by splenocytes from autoimmune motheaten mice. McCoy, K.L., Engel, D., Clagett, J. Am. J. Pathol. (1983) [Pubmed]
  2. Growth and differentiation in vitro of the accumulating Lyt-2-/L3T4- subset in lpr mice. Budd, R.C., MacDonald, H.R., Lowenthal, J.W., Davignon, J.L., Izui, S., Cerottini, J.C. J. Immunol. (1985) [Pubmed]
  3. Absence of proteoglycan core protein in cartilage from the cmd/cmd (cartilage matrix deficiency) mouse. Kimata, K., Barrach, H.J., Brown, K.S., Pennypacker, J.P. J. Biol. Chem. (1981) [Pubmed]
  4. The fine structure of the cervical spinal cord, ventral root and brachial nerves in the wobbler (wr) mouse. Andrews, J.M. J. Neuropathol. Exp. Neurol. (1975) [Pubmed]
  5. Analyses of the NRAMP1 and IFN-gammaR1 genes in women with Mycobacterium avium-intracellulare pulmonary disease. Huang, J.H., Oefner, P.J., Adi, V., Ratnam, K., Ruoss, S.J., Trako, E., Kao, P.N. Am. J. Respir. Crit. Care Med. (1998) [Pubmed]
  6. The biochemistry of Parkinson's disease. Cookson, M.R. Annu. Rev. Biochem. (2005) [Pubmed]
  7. Peripheral nerve grafts in hereditary leukodystrophic mutant mice (twitcher). Scaravilli, F., Jacobs, J.M. Nature (1981) [Pubmed]
  8. Flow cytometry analysis of T cells and continuous T-cell lines from autoimmune MRL/l mice. Lewis, D.E., Giorgi, J.V., Warner, N.L. Nature (1981) [Pubmed]
  9. Three recessive loci required for insulin-dependent diabetes in nonobese diabetic mice. Prochazka, M., Leiter, E.H., Serreze, D.V., Coleman, D.L. Science (1987) [Pubmed]
  10. Beta-glucuronidase activity is present in the microscopic epididymis of the Tfm/Y mouse. Scott, J.E., Blecher, S.R. Dev. Genet. (1987) [Pubmed]
  11. Genetic dissection of SLE: SLE1 and FAS impact alternate pathways leading to lymphoproliferative autoimmunity. Shi, X., Xie, C., Kreska, D., Richardson, J.A., Mohan, C. J. Exp. Med. (2002) [Pubmed]
  12. Meiosis and early cleavage in Drosophila melanogaster eggs: effects of the claret-non-disjunctional mutation. Kimble, M., Church, K. J. Cell. Sci. (1983) [Pubmed]
  13. Genetic animal models of depression and ethanol preference provide support for cholinergic and serotonergic involvement in depression and alcoholism. Overstreet, D.H., Rezvani, A.H., Janowsky, D.S. Biol. Psychiatry (1992) [Pubmed]
  14. Alport syndrome, mental retardation, midface hypoplasia, and elliptocytosis: a new X linked contiguous gene deletion syndrome? Jonsson, J.J., Renieri, A., Gallagher, P.G., Kashtan, C.E., Cherniske, E.M., Bruttini, M., Piccini, M., Vitelli, F., Ballabio, A., Pober, B.R. J. Med. Genet. (1998) [Pubmed]
  15. Absence of overexpression of p53 protein by intestinal carcinoid tumours. O'Dowd, G., Gosney, J.R. J. Pathol. (1995) [Pubmed]
  16. A novel lymphoproliferative/autoimmune syndrome resembling murine lpr/gld disease. Sneller, M.C., Straus, S.E., Jaffe, E.S., Jaffe, J.S., Fleisher, T.A., Stetler-Stevenson, M., Strober, W. J. Clin. Invest. (1992) [Pubmed]
  17. Differential endotoxin sensitivity of lymphocytes and macrophages from mice with an X-linked defect in B cell maturation. Rosenstreich, D.L., Vogel, S.N., Jacques, A., Wahl, L.M., Scher, I., Mergenhagen, S.E. J. Immunol. (1978) [Pubmed]
  18. Genetic defect in T lymphocyte-specific homing into peripheral lymph nodes. Nakano, H., Tamura, T., Yoshimoto, T., Yagita, H., Miyasaka, M., Butcher, E.C., Nariuchi, H., Kakiuchi, T., Matsuzawa, A. Eur. J. Immunol. (1997) [Pubmed]
  19. Changes in the levels of seven proteins involved in polypeptide folding and transport during endosperm development of two barley genotypes differing in storage protein localisation. Møgelsvang, S., Simpson, D.J. Plant Mol. Biol. (1998) [Pubmed]
  20. The induction of tail malformations in trisomy 16 mouse fetuses heterozygous for the curly tail recessive gene. Crolla, J.A., Lakeman, S.K., Seller, M.J. Genet. Res. (1990) [Pubmed]
  21. Genetic control of melatonin synthesis in the pineal gland of the mouse. Ebihara, S., Marks, T., Hudson, D.J., Menaker, M. Science (1986) [Pubmed]
  22. More evidence for the recessive inheritance of selective adult type lactose malabsorption. Sahi, T., Launiala, K. Gastroenterology (1977) [Pubmed]
  23. Expression of airway hyperreactivity to acetylcholine as a simple autosomal recessive trait in mice. Levitt, R.C., Mitzner, W. FASEB J. (1988) [Pubmed]
  24. Physiological effects of fenpropimorph on wild-type Saccharomyces cerevisiae and fenpropimorph-resistant mutants. Lorenz, R.T., Parks, L.W. Antimicrob. Agents Chemother. (1991) [Pubmed]
  25. Single gene controlling black eyes found from the intercross of two yellow-eyed strains of Heliothis virescens. Cho, S.Y., Payne, G.T., Brown, T.M. Genesis (2003) [Pubmed]
  26. Familial screening for genetic haemochromatosis by means of DNA markers. Yaouanq, J., el Kahloun, A., Chorney, M., Jouanolle, A.M., Mauvieux, V., Perichon, M., Blayau, M., Pontarotti, P., Le Gall, J.Y., David, V. J. Med. Genet. (1992) [Pubmed]
  27. Natural killer-like T cells develop in SJL mice despite genetically distinct defects in NK1.1 expression and in inducible interleukin-4 production. Beutner, U., Launois, P., Ohteki, T., Louis, J.A., MacDonald, H.R. Eur. J. Immunol. (1997) [Pubmed]
  28. Genetic polymorphism of human deoxyribonuclease II (DNase II): low activity levels in urine and leukocytes are due to an autosomal recessive allele. Yasuda, T., Nadano, D., Sawazaki, K., Kishi, K. Ann. Hum. Genet. (1992) [Pubmed]
  29. Polygenic control of the expression of biological activities of an antitumor polysaccharide, lentinan. Maeda, Y.Y., Takahama, S., Kohara, Y., Yonekawa, H. Int. J. Immunopharmacol. (1997) [Pubmed]
  30. Novel mutation in cardiac troponin I in recessive idiopathic dilated cardiomyopathy. Murphy, R.T., Mogensen, J., Shaw, A., Kubo, T., Hughes, S., McKenna, W.J. Lancet (2004) [Pubmed]
  31. Gene complex controlling growth and fertility linked to the major histocompatibility complex in the rat. Gill, T.J., Kunz, H.W. Am. J. Pathol. (1979) [Pubmed]
  32. Effector mechanism of experimental autoimmune sialadenitis in the mouse model for primary Sjögren's syndrome. Hayashi, Y., Haneji, N., Hamano, H., Yanagi, K., Takahashi, M., Ishimaru, N. Cell. Immunol. (1996) [Pubmed]
WikiGenes - Universities