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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Spink5  -  serine peptidase inhibitor, Kazal type 5

Mus musculus

Synonyms: 2310065D10Rik, AV238912, LEKT1, LETK1, VAKT1
 
 
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High impact information on Spink5

  • Spink5-deficient mice mimic Netherton syndrome through degradation of desmoglein 1 by epidermal protease hyperactivity [1].
  • Here we report mapping of the murine Spink5 gene to chromosome 18 and its characterization [2].
  • Our data indicate that mouse Spink5/Lekti, like its human counterpart, is involved in the control of epithelial tissue homeostasis, but also highlight specific features of the murine gene and protein [2].

References

  1. Spink5-deficient mice mimic Netherton syndrome through degradation of desmoglein 1 by epidermal protease hyperactivity. Descargues, P., Deraison, C., Bonnart, C., Kreft, M., Kishibe, M., Ishida-Yamamoto, A., Elias, P., Barrandon, Y., Zambruno, G., Sonnenberg, A., Hovnanian, A. Nat. Genet. (2005) [Pubmed]
  2. Characterization and expression analysis of the Spink5 gene, the mouse ortholog of the defective gene in Netherton syndrome. Galliano, M.F., Roccasecca, R.M., Descargues, P., Micheloni, A., Levy, E., Zambruno, G., D'Alessio, M., Hovnanian, A. Genomics (2005) [Pubmed]
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