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Gene Review

DNAJC7  -  DnaJ (Hsp40) homolog, subfamily C, member 7

Homo sapiens

Synonyms: DJ11, DJC7, DnaJ homolog subfamily C member 7, TPR repeat protein 2, TPR2, ...
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High impact information on DNAJC7

  • The other loss-of-interaction mutations and most suppressor mutations localized in short, exposed, intra-repeat loops of TPR2, TPR3, and TPR6, which are predicted to mediate direct interaction with PTS1 amino acids [1].
  • A multiple amino acid sequence alignment of this subgroup of DNA polymerases led to the identification of two insertions, TPR-1 and TPR-2, in the polymerisation domain [2].
  • A highly conserved sequence in TPR2 was altered by deletion or single amino acid replacement [3].
  • The J domain of Tpr2 regulates its interaction with the proapoptotic and cell-cycle checkpoint protein, Rad9 [4].
  • The second, defined by cDNA tpr2, maps to human chromosome 17q11.2-23 [5].

Biological context of DNAJC7

  • Molecular genetic maps were constructed for two full-sib populations, TTC1 and TTC2, derived from two Leymus triticoides x Leymus cinereus hybrids and one common Leymus triticoides tester [6].


  1. Recognition of peroxisomal targeting signal type 1 by the import receptor Pex5p. Klein, A.T., Barnett, P., Bottger, G., Konings, D., Tabak, H.F., Distel, B. J. Biol. Chem. (2001) [Pubmed]
  2. A conserved insertion in protein-primed DNA polymerases is involved in primer terminus stabilisation. Dufour, E., Rodríguez, I., Lázaro, J.M., de Vega, M., Salas, M. J. Mol. Biol. (2003) [Pubmed]
  3. Heat shock cognate protein 70 chaperone-binding site in the co-chaperone murine stress-inducible protein 1 maps to within three consecutive tetratricopeptide repeat motifs. Van Der Spuy, J., Kana, B.D., Dirr, H.W., Blatch, G.L. Biochem. J. (2000) [Pubmed]
  4. The J domain of Tpr2 regulates its interaction with the proapoptotic and cell-cycle checkpoint protein, Rad9. Xiang, S.L., Kumano, T., Iwasaki, S.I., Sun, X., Yoshioka, K., Yamamoto, K.C. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  5. Identification and characterization of two novel tetratricopeptide repeat-containing genes. Murthy, A.E., Bernards, A., Church, D., Wasmuth, J., Gusella, J.F. DNA Cell Biol. (1996) [Pubmed]
  6. Molecular genetic linkage maps for allotetraploid Leymus wildryes (Gramineae: Triticeae). Wu, X., Larson, S.R., Hu, Z., Palazzo, A.J., Jones, T.A., Wang, R.R., Jensen, K.B., Chatterton, N.J. Genome (2003) [Pubmed]
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